Biochem Flashcards Preview

My board exam flashcards > Biochem > Flashcards

Flashcards in Biochem Deck (187)
Loading flashcards...
1

Glycogen storage diseases Very Poor Carbohydrate Metabolism

VON GIERKE glucose 6 phosphatase POMPES alpha 1 4 glucosidase CORI alpha 1 6 glucosidase MCARDLE glycogen phosphorylase

2

Glucose transporters not requiring insulin

GLUT 13 brain kidney placenta GLUT 2 liver pancreatic B cell SI Kidney

3

GLUT requiring insulin

GLUT 4 Heart Skeletal muscle Adipocytes

4

GLUT 1

RBC COLON Brain KidneyPlacenta

5

GLUT 3

Brain Kidney Placenta

6

GLUT 5

Small intestines

7

Location of glycolysis

cytoplasm

8

3 carbon end products of glycolysis

Pyruvate or Lactate

9

rate limiting step of glycolysis

PFK 1 from fructose 6 phosphate TO fructose 1 6 bisphosphate

10

3 irreversible steps of glycolysis

1 phosphorylation of glycose via GLUCOKINASE or HEXOKINASE. 2 phosphorylation of fructose 6 phosphate via PFK1. 3 formation of pyruvate via PYRUVATE DEHYDROGENASE.

11

No of ATP from substrate level phosphorylation in Glycolysis

4 ATP

12

No of ATP needed for glycolysis

2 ATP

13

ATP production in glycolysis using KINases ie phosphate transfer into ADP

1 3 biphosphoglycerate and PEP

14

NADH prodc in glycolysis

glycealdehyde 3 phosphate to 1 3 bisphosphoglycerate via a DEHYDROGENASE

15

Malate aspartate shittle liver kidney heart vs glycerol phosphate shuttle in brain and sk ms

Malate 1 NADH to 3 ATP via NADH e acceptor complex I while Glycerol 1 NADH to 2 ATP via FADH e acceptor in complex II

16

organs that are Strictly anaerobic glycolysis

RBC lens cornea medulla of kidney testes WBC

17

NET ATP yield from Glycolysis

Anaerobic 2 ATP. Aerobic ATPs ff NADG 4 or 6 with net ATP of 6 or 8 depending on shuttle used.

18

Function of 2 3 Bisphosphoglycerate

reduces Hgb affinity for O2 hence releasing it. Note fetal hgb has higher 2 3 biphosphoglycerate than mom

19

Arsenic poison competes with

1competes with phosphate as substrate for GLYCERALDEHYDE 3 P DEHYDROGENASE 2 binds lipoic acid so PYRUVATE DEHYDROGENASE wont work therefore no NADH is produced during glycolysis to go into ETC

20

MC enzyme defect in glycolysis

Pyruvate kinase deficiency presents as chronic hemolytic anemia

21

2 enzymed requiring 5 co enzymes

1 pyruvate dehydrogenase 2 Alpha ketogluterate Dehydrogenase of TCA

22

5 co enzymes of the divas Love Never Fails To Conquer

Lipoic acid Niacin riboFADin Thiamine Co enzyme A with B5

23

MCC congenital lactic acidosis

Pyruvate dehydrogenase deficiency X linked

24

Site of TCA

mitochondrial matrix EXCEPT succinate dehydrogenase aka Complex II in inner mitochondria

25

substrate of TCA

ACETYL COA fr pyruvate

26

UP above acid vs base

above pka. Acid is unprotonated with negative charge. Base is unprotonated with charge. Charged is water soluble. Uncharged is lipid soluble.

27

rate limiting step of TCA

isocitrate to alpha ketogluterate via isocitrate dehydrogenase

28

Steps in TCA Cindy is Kind So She Forgives More Often

Citrate Isocitrate Ketogluterate Succinyl Coa Succinate Fumarate Malate Oxaacetate

29

dehydrogenase always produces an

NADH

30

Citrate

fatty acid synthesis