Biochem - metabolism :) Flashcards Preview

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Flashcards in Biochem - metabolism :) Deck (45):
1

Rate determining step: glycolysis

PFK-1

2

Rate determining step: Gluconeogenesis

fructose-1,6-bisphosphatase

3

Rate determining step: TCA cycle

isocitrate dehydrogenase

4

Rate determining step: glyogenesis

glycogen synthase

5

Rate determining step: glycogenolysis

glycogen phosphorylase

6

Rate determining step: HMP shunt

glucose-6-phosphate dehydrogenase

7

Rate determining step: de novo pyrimadine synthesis

carbamoyl phosphate synthetase II (CPS2)

8

Rate determining step: de novo purine synthesis

glutamine PRPP amidotransferase

9

Rate determining step: Urea cycle

carbamoyl phosphate synthetase I

10

Rate determining step: fatty acid synthesis

acetyl coa carboxylase

11

Rate determining step: Fatty acid oxidation

Carnitine acyltransferase I

12

Rate determining step: Ketogenesis

HMG CoA synthase

13

Rate determining step: Cholesterol synthesis

HMG CoA reductase

14

Gibbs free energy equation

delta G = deltaH - TdeltaS

15

Drugs that inhibit complex I

rotenone
mPP
amytal

16

Drugs that inhibit complex III

antimycin A

17

Things that inhibit complex IV

CO
cyanide
sodium azide (N3-)
H2S

18

Things that inhibit atp synthase (complex V)

oligomycin

19

4 sites of HMP shunt existence

1) rbcs
2) mammary glands
3) liver
4) adrenal cortex

20

fructokinase deficiency causes

essential fructosuria (not a big deal)

21

aldolase B deficiency causes

fructose intolerance (bad)

22

Rx for fructose intolerance

decrease intake of fructose and sucrose

23

galactokinase deficiency

relatively mild, only symptom is infantile cataracts, maybe some failure to track objects/lack of social smile.

24

absence of galactose 1 phosphate uridyltransferase

classic galactosemia
failure to thrive, jaundice, hepatomegaly, infantile catarcats, disability, E coli sepsis in neonates = severe symptoms soon after starting feeding

25

Rx classic galactosemia

exclude galactose and lactose in diet

26

lack of what enzyme can lead to sorbitol induced osmotic damage

sorbitol dehydrogenase

27

what cells lack sorbitol dehydrogenase

lens, schwann cells, retina, kidneys

28

acidic amino acids

aspartic acid and glutamic acid
negative at body pH

29

basic amino acids

arginine, lysine, histidine
positive at body pH except histidine =no charge

30

essential amino acids

PVT TIM HaLL

phenylalanine
valine
threonine
tryptophan
isoleucine
lysine
histidine
leucine
lysine

31

ketogenic amino acids

leucine and lysine

32

fatty acid oxidation (beta oxidation) location

mitochondria

33

glycolysis location

cytosol

34

acetyl-coa production location

mitochondria

35

heme synthesis location

mitochondria and cytosol

36

tca cycle location

mitchondria

37

fatty acid synthesis location

cytosol

38

urea cycle location

both mitochondria and cytosol

39

oxidative phosphorylation location

mitochondria

40

gluconeogenesis location

both mitochondria and cytosol

41

HMP shunt location

cytoplasm

42

protein syntehsis (RER) loctaion

cytoplasm

43

ketogenesis location

mitochondria

44

cholesterol syntehsis

cytoplasm

45

steroid synthesis location

cytoplasm