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Flashcards in GI Deck (34):
1

common ending of H2 blockers

-dine

2

cimetidine/ranitidine/famotidine/nizatidine MOA

H2 receptor blockers - reduce H2 secretion by parietal cells

3

cimitidine side effects (3)

1) cyp 450 inhibitor
2)anti-androgen effects (prolactin release, gynecomastia, impotence, decreased libido)
3) can cross bbb and placenta

4

orlistat clinical use

weight loss

5

orlistat MOA

inhibits gastric/pancreatic lipase --> decreases breakdown and absorption of dietary fats

6

orlistat side effects

steatorrhea, decreased absoprtion of fat soluble vitamins

7

metaclopramide use

diabetic and post surgery gastroparesis, antiemetic

8

Metoclopromide MOA

D2 receptor antagonist. Increases resting tone contractility, LES tone, motility but does not affect transport time

9

Metoclopramide side effects

increased parkinsonian effects (Tardive dyskinesia). Restlessness, drowsiness, fatigue, depression, diarrhea

10

Metoclopramide has drug interactions with what drugs

diabetic agents and digoxin

11

metoclopramide is contraindicated in what patients

patients with small bowel obstruction or parkinson disease (due to d1 receptor blockade)

12

ondansetron MOA

5ht3 antagonist- decreases vagal stimulation

13

ondansetron use

controls post-op vomiting, post-chemo vomiting, can help with travelers diarrhea/n/v

14

ondansetron side effects

headache, constipation, qt interval prolonging

15

sulfasalazine is a combination of what two things

sulfapyridine (antibacterial) and 5-aminosalicylic acid (anti-inflammatory)

16

how is sulfasalazine activated

by gut flora

17

sulfasalazine side effects

sulfa allergy, reversible oligospermia

18

magnesium hydroxide moa

osmotic laxative

19

magnesium citrate moa

osmotic laxative

20

polyethylene glycol moa

osmotic laxative

21

lactulose moa

osmotic laxative

22

how does lactulose help with hepatic encephalopathy

gut flora degrade lactulose into metabolites (lactic acid and acetic acid) that promotes nitrogen excretion as NH4+.

23

osmotic laxactives clinical use

constipation

24

antacids can cause what electrolyte abnormality

hypokalemia

25

aluminum hydroxide side effects

constipation, hypophosphatemia, proximal muscle weakness, osteodystrophy, seizures
(aluminimum of feces)

26

calcium carbonate side effects

hypercalcemia, high rebound acid
can chelate and decrease effectiveness of other drugs (ex. tetracyclines)

27

magnesium hydroxide side effects

diarrhea, hyporeflexia, hypotension, cardiac arrest
must go = mg

28

octreotide MOA

long acting somatostatin analog - inhibits actions of many vasodilatory hormones (causes vasoconstriction)

29

misoprostol MOA

PGE1 analog - increases production and secretion of gastric mucous barrier. decreases gastric acid production

30

misoprostol is contraindicated in who

women of childbearing potential - abortifacient

31

PPIs cause increased risk of what infections

c. diff

32

bismuth moa

binds to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in the mucous layer

33

PPI moa

irreversibly inhibit H/K atpase in stomach pareital cells

34

PPIs affect what electrolyte with long term use

decrease serum magnesium