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Flashcards in Immuno Deck (95):
1

Lymph drainage: head and neck

cervical

2

Lymph drainage: lungs

hilar

3

Lymph drainage: Trachea and esophageal

mediastinal

4

Lymph drainage: Upper limb, breast, skin above umbilicus

axillary

5

Lymph drainage: Liver, stomach, spleen, pancreas, upper duodenum

celiac

6

Lymph drainage: lower duodenum, jejunum, ileum, colon, up to splenic flexure

superior mesenteric

7

Lymph drainage: colon from splenic flexure to upper rectum

inferior mesenteric

8

Lymph drainage: Lower rectum to anal canal (above pectinate line), bladder, vagina (middle third), prostate

internal iliac

9

Lymph drainage: testes, ovaries, kidneys, uterus

para-aortic

10

Lymph drainage: Anal canal (below pectinate line), skin below umbilicus except popliteal territory, scrotum

superficial inguinal

11

Lymph drainage: dorsolateral foot, posterior calf

popliteal

12

HLA: hemochromatosis

A3

13

HLA: PAIR syndromes (psoriatic arthritis, ankylosing spondylitis, IBD, Reactive arthritis)

B27

14

HLA: Celiac disease

DQ2/DQ8

15

HLA: MS

DR2

16

HLA: hay fever

DR2

17

HLA: SLE

DR2/DR3

18

HLA: Goodpasture

DR2

19

HLA: DM 1

DR3, DR4

20

HLA: Graves disease

DR3

21

HLA: Hashimoto

DR3/ DR5

22

HLA: Rheumatoid arthritis

DR4

23

HLA: Pernicious anemia/b12 deficiency

DR5

24

MHC class 1 are encoded by

HLA-A, HLA-B, HLA-C

25

MHC class II are encoded by

HLA-DQ, HLA-DP, HLA-DR

26

What cytokines increase NK cell proliferation?

IL-2, IL-12, IFN alpha, IFN beta

27

Name the disease: Anti-ACh receptor

Myasthenia gravis

28

Name the disease: Anti-BM

Goodpasture syndrome

29

Name the disease: Anticardiolipin

SLE/antiphosholipid syndrome

30

Name the disease: anticentromere

CREST scleroderma (limited)

31

Name the disease: Anti-desmosome (anti-desmoglein)

pemphigus vulgaris

32

Name the disease: Anti-dsDNA

SLE

33

Name the disease: Anti-Smith

SLE

34

Name the disease: Anti-glutamic acid decarboxylase (GAD-65)

Type 1 DM

35

Name the disease: Anti-hemidesmosome

Bullous pemphigoid

36

Name the disease: Anti-histone

Drug induced lupus

37

Name the disease: Anti-Jo-1

polymyositis/dermatomyositis

38

Name the disease: Anti-microsomal

Hashimoto thyroiditis

39

Name the disease: Anti-thyroglobulin

hashimoto thyroiditis

40

Name the disease: Antimitochondrial

Primary biliary cirrhosis

41

Name the disease: Antinuclear

SLE (nonspecific)

42

Name the disease: Anti-parietal cell

Pernicious anemia

43

Name the disease: Anti-SSA

Sjoren Syndrome

44

Name the disease: Anti-SSB

Sjrogen syndrome

45

Name the disease: Anti-SCL 70

Scleroderma

46

Name the disease: Anti-DNA topoisomeriase 1

scleroderma

47

Name the disease: Anti-smooth muscle

autoimmune hepatitis

48

Name the disease: Anti-TSH receptor

Graves disease

49

Name the disease: Anti-Ro/Anti-La

Sjrogen Syndrome

50

Name the disease: Anti-U1 RNP

Mixed connective tissue disease

51

Name the disease: IgA anti-endomysial

Celiac

52

Name the disease: anti-tissue transglutaminase

Celiac

53

Name the disease: anti-CCP

Rheumatoid arthritis

54

Name the disease: p-ANCA

microscopic polyangiitis, Churg strauss

55

Name the disease: c-ANCA

Wegners granulomatosis

56

Alemtuzumab MOA and clinical use

Targets cd52
used for CLL

57

Bevacizumab MOA and clinical use

Targets VEGF
Used for colorectal cancer and renal cell carcinoma

58

Cetuximab MOA and clinical use

Targets EGFR
Used for stage IV colorectal cancer, head and neck cancer

59

Rituximab MOA and clinical use

Targets CD20 (lyses B cells)
Used for B cell non-Hodgkins lymphoma, CLL, RA, ITP

60

Tratuzumab MOA and clinical use

Targets HER2/Neu
Used for breast cancer

61

Adalimumab MOA and clinical use

Targets soluble TNF-alpha
Used in IBD, RA, ankylosing spondylitis, psoriasis

62

Infliximab MOA and clinical use

Tarets soluble TNF alpha
USed in IBD, RA, ankylosing spondylitis, psoriasis

63

Eculizumab MOA and clinical use

Targets complement protein C5
Used for PNH

64

Natalizumab MOA and clinical use

Target alpha4 integrin --> WBC adhesion molecule
USed in MS, Crohns
SIDE EFFECT: risk of pML in patients with JC virus

65

Abciximab MOA and clinical use

Targets platelet glycoprotein IIb/IIIa
USed as an antiplatelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

66

Denosumab MOA and clinical use

Targets RANKL
Used in osteoporosis to inhibit osteoclast maturation

67

Antidote for digoxin toxicity

digoxin Fab immune fab

68

Omalizumab MOA and clinical use

Targets IgE
Used in allergic asthma, prevents IgE binding to FceRI

69

Palavizumab MOA and clinical use

Targets RSV F protein
RSV prophylaxis for high risk infants

70

Ranibizumab MOA and clinical use

targets VEGF
used for neovascular age related macular degeneration

71

Bevacizumab MOA and clinical use

targets VEGF
used for neovascular age related macular degeneration

72

Cyclosporine MOA

Calcineurin inhibitor - binds cyclophilin - blocks T cell activation by preventing IL-2 transcription

73

Cyclosporine Side effects

nephrotoxicity, hypertension, neurotoxicity, gingival hyperplasia, hirsutism

74

Tacrolimus MOA

Calcineurin inhibitor - binds FK506 binding protein (FKBP) to prevent IL-2 transcription thus blocking T cell activation

75

Tacrolimus Side effects

neurotoxicity, nephrotoxic but no gingival hyperplasia or hirsutism

76

Sirolimus (rapamycin) MOA

mTOR inhibitor - also binds FKBP - blocks T and B cell activation/differentiation by preventing response to IL-2

77

Cyclosporine has synergistic effect with which drug

sirolimus

78

Daclizumab MOA

monoclonal antibodies that block iL-2r

79

Basiliximab moa

monoclonal antibodies that block IL-2R

80

azathioprine MOA

blocks lymphocyte proliferation by blocking nucleotide synthesis

81

azathioprine side effects

bone marrow supression (leukopenia, anemia, thrombocytopenia)

82

azathiprine is metabolized by what

XO

83

Glucocorticoids MOA

inhibit NFKB, suppress both b and t cell function by decreasing transcription of many cytokines

84

mycophenolate moa

inhibits IMP dehydrogenase and thus inhibits guanine synthesis - prevents lymphocyte proliferation

85

thalidomide moa

supresses TNF alpha production, increases NK cells and IL-2 - used in erythema nodosum leprosy (hansens)

86

Aldesleukin

il-2, used in RCC and metastatic melaonoma

87

Epoetin alfa

erythropoietin -anemia, esp. if in renal failure

88

filgrastim

G-CSF (recovery of bone marrow)

89

sargramostim

GM-CSF recovery of bone marrow

90

IFN alpha used in

chronic hep B and C, kaposi, malinant melanoma, hairy cell leukoemia

91

IFN beta used in

MS

92

ifn gamma used in

chronic granulomatous disorder

93

romiplostim

used in thrombocytopenia

94

eltrombopag

thrombocytopenia

95

oprelvekin

IL-11 also thrombocytopenia