Immuno Flashcards
(95 cards)
1
Q
Lymph drainage: head and neck
A
cervical
2
Q
Lymph drainage: lungs
A
hilar
3
Q
Lymph drainage: Trachea and esophageal
A
mediastinal
4
Q
Lymph drainage: Upper limb, breast, skin above umbilicus
A
axillary
5
Q
Lymph drainage: Liver, stomach, spleen, pancreas, upper duodenum
A
celiac
6
Q
Lymph drainage: lower duodenum, jejunum, ileum, colon, up to splenic flexure
A
superior mesenteric
7
Q
Lymph drainage: colon from splenic flexure to upper rectum
A
inferior mesenteric
8
Q
Lymph drainage: Lower rectum to anal canal (above pectinate line), bladder, vagina (middle third), prostate
A
internal iliac
9
Q
Lymph drainage: testes, ovaries, kidneys, uterus
A
para-aortic
10
Q
Lymph drainage: Anal canal (below pectinate line), skin below umbilicus except popliteal territory, scrotum
A
superficial inguinal
11
Q
Lymph drainage: dorsolateral foot, posterior calf
A
popliteal
12
Q
HLA: hemochromatosis
A
A3
13
Q
HLA: PAIR syndromes (psoriatic arthritis, ankylosing spondylitis, IBD, Reactive arthritis)
A
B27
14
Q
HLA: Celiac disease
A
DQ2/DQ8
15
Q
HLA: MS
A
DR2
16
Q
HLA: hay fever
A
DR2
17
Q
HLA: SLE
A
DR2/DR3
18
Q
HLA: Goodpasture
A
DR2
19
Q
HLA: DM 1
A
DR3, DR4
20
Q
HLA: Graves disease
A
DR3
21
Q
HLA: Hashimoto
A
DR3/ DR5
22
Q
HLA: Rheumatoid arthritis
A
DR4
23
Q
HLA: Pernicious anemia/b12 deficiency
A
DR5
24
Q
MHC class 1 are encoded by
A
HLA-A, HLA-B, HLA-C
25
MHC class II are encoded by
HLA-DQ, HLA-DP, HLA-DR
26
What cytokines increase NK cell proliferation?
IL-2, IL-12, IFN alpha, IFN beta
27
Name the disease: Anti-ACh receptor
Myasthenia gravis
28
Name the disease: Anti-BM
Goodpasture syndrome
29
Name the disease: Anticardiolipin
SLE/antiphosholipid syndrome
30
Name the disease: anticentromere
CREST scleroderma (limited)
31
Name the disease: Anti-desmosome (anti-desmoglein)
pemphigus vulgaris
32
Name the disease: Anti-dsDNA
SLE
33
Name the disease: Anti-Smith
SLE
34
Name the disease: Anti-glutamic acid decarboxylase (GAD-65)
Type 1 DM
35
Name the disease: Anti-hemidesmosome
Bullous pemphigoid
36
Name the disease: Anti-histone
Drug induced lupus
37
Name the disease: Anti-Jo-1
polymyositis/dermatomyositis
38
Name the disease: Anti-microsomal
Hashimoto thyroiditis
39
Name the disease: Anti-thyroglobulin
hashimoto thyroiditis
40
Name the disease: Antimitochondrial
Primary biliary cirrhosis
41
Name the disease: Antinuclear
SLE (nonspecific)
42
Name the disease: Anti-parietal cell
Pernicious anemia
43
Name the disease: Anti-SSA
Sjoren Syndrome
44
Name the disease: Anti-SSB
Sjrogen syndrome
45
Name the disease: Anti-SCL 70
Scleroderma
46
Name the disease: Anti-DNA topoisomeriase 1
scleroderma
47
Name the disease: Anti-smooth muscle
autoimmune hepatitis
48
Name the disease: Anti-TSH receptor
Graves disease
49
Name the disease: Anti-Ro/Anti-La
Sjrogen Syndrome
50
Name the disease: Anti-U1 RNP
Mixed connective tissue disease
51
Name the disease: IgA anti-endomysial
Celiac
52
Name the disease: anti-tissue transglutaminase
Celiac
53
Name the disease: anti-CCP
Rheumatoid arthritis
54
Name the disease: p-ANCA
microscopic polyangiitis, Churg strauss
55
Name the disease: c-ANCA
Wegners granulomatosis
56
Alemtuzumab MOA and clinical use
Targets cd52
| used for CLL
57
Bevacizumab MOA and clinical use
Targets VEGF
| Used for colorectal cancer and renal cell carcinoma
58
Cetuximab MOA and clinical use
Targets EGFR
| Used for stage IV colorectal cancer, head and neck cancer
59
Rituximab MOA and clinical use
```
Targets CD20 (lyses B cells)
Used for B cell non-Hodgkins lymphoma, CLL, RA, ITP
```
60
Tratuzumab MOA and clinical use
Targets HER2/Neu
| Used for breast cancer
61
Adalimumab MOA and clinical use
Targets soluble TNF-alpha
| Used in IBD, RA, ankylosing spondylitis, psoriasis
62
Infliximab MOA and clinical use
Tarets soluble TNF alpha
| USed in IBD, RA, ankylosing spondylitis, psoriasis
63
Eculizumab MOA and clinical use
Targets complement protein C5
| Used for PNH
64
Natalizumab MOA and clinical use
Target alpha4 integrin --> WBC adhesion molecule
USed in MS, Crohns
SIDE EFFECT: risk of pML in patients with JC virus
65
Abciximab MOA and clinical use
Targets platelet glycoprotein IIb/IIIa
USed as an antiplatelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention
66
Denosumab MOA and clinical use
Targets RANKL
| Used in osteoporosis to inhibit osteoclast maturation
67
Antidote for digoxin toxicity
digoxin Fab immune fab
68
Omalizumab MOA and clinical use
Targets IgE
| Used in allergic asthma, prevents IgE binding to FceRI
69
Palavizumab MOA and clinical use
Targets RSV F protein
| RSV prophylaxis for high risk infants
70
Ranibizumab MOA and clinical use
targets VEGF
| used for neovascular age related macular degeneration
71
Bevacizumab MOA and clinical use
targets VEGF
| used for neovascular age related macular degeneration
72
Cyclosporine MOA
Calcineurin inhibitor - binds cyclophilin - blocks T cell activation by preventing IL-2 transcription
73
Cyclosporine Side effects
nephrotoxicity, hypertension, neurotoxicity, gingival hyperplasia, hirsutism
74
Tacrolimus MOA
Calcineurin inhibitor - binds FK506 binding protein (FKBP) to prevent IL-2 transcription thus blocking T cell activation
75
Tacrolimus Side effects
neurotoxicity, nephrotoxic but no gingival hyperplasia or hirsutism
76
Sirolimus (rapamycin) MOA
mTOR inhibitor - also binds FKBP - blocks T and B cell activation/differentiation by preventing response to IL-2
77
Cyclosporine has synergistic effect with which drug
sirolimus
78
Daclizumab MOA
monoclonal antibodies that block iL-2r
79
Basiliximab moa
monoclonal antibodies that block IL-2R
80
azathioprine MOA
blocks lymphocyte proliferation by blocking nucleotide synthesis
81
azathioprine side effects
bone marrow supression (leukopenia, anemia, thrombocytopenia)
82
azathiprine is metabolized by what
XO
83
Glucocorticoids MOA
inhibit NFKB, suppress both b and t cell function by decreasing transcription of many cytokines
84
mycophenolate moa
inhibits IMP dehydrogenase and thus inhibits guanine synthesis - prevents lymphocyte proliferation
85
thalidomide moa
supresses TNF alpha production, increases NK cells and IL-2 - used in erythema nodosum leprosy (hansens)
86
Aldesleukin
il-2, used in RCC and metastatic melaonoma
87
Epoetin alfa
erythropoietin -anemia, esp. if in renal failure
88
filgrastim
G-CSF (recovery of bone marrow)
89
sargramostim
GM-CSF recovery of bone marrow
90
IFN alpha used in
chronic hep B and C, kaposi, malinant melanoma, hairy cell leukoemia
91
IFN beta used in
MS
92
ifn gamma used in
chronic granulomatous disorder
93
romiplostim
used in thrombocytopenia
94
eltrombopag
thrombocytopenia
95
oprelvekin
IL-11 also thrombocytopenia
