Biopharmaceutics Flashcards Preview

Pharmaceutics Spring 2016 > Biopharmaceutics > Flashcards

Flashcards in Biopharmaceutics Deck (42)
1

drug absorption

movement of drug from the site of administration into the blood

2

bioavailability

RATE and EXTENT to which the active ingredient or moiety is absorbed from a drug product and becomes available at the site of action

3

Biopharmaceutics examines what? (4)

-interrelationship between PHYSICAL and CHEMICAL properties of a DRUG
-PATHOLOGY and normal PHYSIOLOGY of the PATIENT
-DOSAGE FORM in which the drug was given
-route of the dosage on the bioavailability

4

API

active pharmaceutical ingredient

5

T/F Excipients effect the rate or extent of absorption of a drug although they are inactive

TRUE

6

What types of things are considered when making a drug product design? (7)

-therapeutic objective (rapid action)
-drug
-route of administration
-dosage and regimen
-type of product
-excipients
-manufacturing method

7

T/F The drug DOES NOT have to be in solution to be absorbed

FALSE: MUST

8

Movement of Drugs through the body (3)

Absorption--> Distribution-->Elimination

9

absorption

movement of drug from where it was administered -->through a membrane-->into the blood

10

T/F Metabolites are found in the blood and are usually NOT active

TRUE

11

distribution

drug moves into certain tissues--> cause a pharmacologic effect

12

pharmacologic effect

when drug lands on a receptor

13

T/F The drug that is released after the pharmacologic effect is a different drug chemically than what was administered

FALSE: the same drug

14

elimination

removing the dug from the body

15

excretion

elimination of UNCHANGED drug

16

Most drugs are excreted through the ______

urine

17

metabolism

a CHEMICAL CHANGE in the drug by the body

18

Following extravascular administration, _______ must occur for a ______ effect from the drug

absorption; system

19

extravascular

outside the vascular system (blood vessels)

20

Samples of the _____ are used to determine the amount of drug being absorbed

blood

21

Concentration of Drug in the Blood?
The concentration of the drug will ____, then it will slowly ____ (via tissue sites or elimination)

increase; decrease

22

Why are drug concentrations more often measured in plasma rather than whole blood or serum?

changes in plasma concentration reflect changes in concentrations in other areas of the body

23

Serum vs. Plasma

serum: you allow the blood to clot
plasma: an anticoagulant is added/placed in the blood-->easier to collect

24

Plasma vs. Whole Blood

whole blood: difficult to analyze
plasma blood: easy to analyze

25

MEC abbreviation

minimum effective concentration

26

MEC ...

there has to be a certain concentration of drug in the plasma before you see certain pharmacologic effects

27

MTC abbreviation

minimum toxic concentration

28

MTC .... (2)

-if you exceed this concentration you will begin to see toxicity
-side effects are often seen if you exceed this number

29

onset time

time when therapeutic effect begins to be observed

30

duration (2)

-time that drug remains above MEC
-response from drug occurs during this time

31

intensity

related to the number of receptors with which the drug interacts

32

The ______ receptors engaged the higher the intensity

more

33

What are the 3 parameters used to determine bioavailability?

-Cmax
-Tmax
-AUC (area under the curve)

34

Cmax (2)

-represents one singe dose of the drug
-the max concentration of drug in the plasma

35

Tmax

the length of time from administration to the max concentration is achieved

36

Increasing amount of absorption; AUC ______

increases

37

Increasing amount of absorption; Cmax _____

increases

38

Increasing amount of absorption; Tmax _____

not effected

39

Increasing rate of absorption; AUC _____

not effected

40

Increasing rate of absorption; Cmax _____

increases

41

Increasing rate of absorption; Tmax ______

decreases

42

see graphs

review graphs