Flashcards in Parenterals Part B Deck (63)
Total parenteral nutrition (TPN)
-used to provide nutrients to patients who can not take in nutrients orally
TPNs typically contain: (3)
-amino acid (protein)
Base solutions are known as....
Macronutrients (amino acid solutions, dextrose, IV fat)
TNA or three in one admixture contain (3)
What is the problem with 3 in 1 admixtures?
emulsions are typically opaque (milky white) which makes it hard to see incompatibilities
If TPN is going to be going on for a while you may need both....
macronutrients and micronutrients
micronutrients are known as
What is the problem with using high concentrations of dextrose?
it is no longer isotonic, but hypertonic
T/F You only want to use manual compounding if it is required. Automated is better.
TPN manual Gravity method for compounding?
special IV bag with transfer leads attached
TPN automated compounding? (2)
-reduces potential error and contamination
the complete destruction of all living organisms and their spores
Methods used for sterilization (5)
-dry heat sterilization
-sterilization by filtration
Sterility assurance level
What is the SAL of terminal sterilization?filter sterilization?
terminal: 10^-6 (1 in a million)
filter: 10^-3 (1 in a thousand)
T/F Filter Sterilization is terminal sterilization
FALSE: IS NOT
Steam Sterilization is also known as .....
autoclaving (the best method)
T/F Autoclaving does not destroy pyrogens
TRUE; the material is pyrogen free due to distillation that uses WFSI
Steam Sterilization (2)
-moist heat causes denaturation of proteins
-saturated steam under pressure in autoclave 121 degrees celsius
Which of the following ampuls can be sterilized in an autoclave machine?
-drug in oil
-drug in WFSI
drug in WFSI because it makes its own pressure causing the pressure to be the same on the inside and outside of the ampul
T/F Dry Heat sterilization uses a higher temperature for a longer period of time than steam sterilization
Dry Heat Sterilization (3)
-dehydration follow by oxidation
-glassware can be covered w/aluminum foil and sterilized
Which of the following ampuls can be sterilized in by dry heat?
-drug in oil
-drug in WFSI
drug in oil
Filtration Sterilization (3)
-suitable for heat sensitive material (protein)
-does not remove pyrogens
-physical removal of microorganisms by 0.2 micron membrane filter
What tests checks the integrity of the filter (makes sure there is no breaks in the filter)?
Bubble point test
Pressure hold test
Gas sterilization (2)
-exposure to ethylene oxide gas diluted with an inert gas
-for heat and moisture sensitive material
In a gas chamber during sterilization what is controlled? (4)
Ionizing Radiation Sterilization (2)
-gamma radiation from cobalt-60
-used for medical devices and hospital supplies
Sterilization needs to be validated, how is this possible? (4)
-color change indicators