Parenterals Part B Flashcards Preview

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Flashcards in Parenterals Part B Deck (63)
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1

Total parenteral nutrition (TPN)

-used to provide nutrients to patients who can not take in nutrients orally

2

TPNs typically contain: (3)

-carb (dextrose)
-lipid (fat)
-amino acid (protein)

3

Base solutions are known as....

Macronutrients (amino acid solutions, dextrose, IV fat)

4

TNA or three in one admixture contain (3)

-IV emulsion
-amino acid
-dextrose

5

What is the problem with 3 in 1 admixtures?

emulsions are typically opaque (milky white) which makes it hard to see incompatibilities

6

If TPN is going to be going on for a while you may need both....

macronutrients and micronutrients

7

micronutrients are known as

electrolytes

8

What is the problem with using high concentrations of dextrose?

it is no longer isotonic, but hypertonic

9

T/F You only want to use manual compounding if it is required. Automated is better.

TRUE

10

TPN manual Gravity method for compounding?

special IV bag with transfer leads attached

11

TPN automated compounding? (2)

-saves time
-reduces potential error and contamination

12

Sterilization?

the complete destruction of all living organisms and their spores

13

Methods used for sterilization (5)

-steam sterilization
-dry heat sterilization
-sterilization by filtration
-gas sterilization
-ionizing radiation

14

SAL abbreviation?

Sterility assurance level

15

What is the SAL of terminal sterilization?filter sterilization?

terminal: 10^-6 (1 in a million)
filter: 10^-3 (1 in a thousand)

16

T/F Filter Sterilization is terminal sterilization

FALSE: IS NOT

17

Steam Sterilization is also known as .....

autoclaving (the best method)

18

T/F Autoclaving does not destroy pyrogens

TRUE; the material is pyrogen free due to distillation that uses WFSI

19

Steam Sterilization (2)

-moist heat causes denaturation of proteins
-saturated steam under pressure in autoclave 121 degrees celsius

20

Which of the following ampuls can be sterilized in an autoclave machine?
-drug in oil
-drug in WFSI

drug in WFSI because it makes its own pressure causing the pressure to be the same on the inside and outside of the ampul

21

T/F Dry Heat sterilization uses a higher temperature for a longer period of time than steam sterilization

TRUE

22

Dry Heat Sterilization (3)

-dehydration follow by oxidation
-removes pyrogens
-glassware can be covered w/aluminum foil and sterilized

23

Which of the following ampuls can be sterilized in by dry heat?
-drug in oil
-drug in WFSI

drug in oil

24

Filtration Sterilization (3)

-suitable for heat sensitive material (protein)
-does not remove pyrogens
-physical removal of microorganisms by 0.2 micron membrane filter

25

What tests checks the integrity of the filter (makes sure there is no breaks in the filter)?

Bubble point test
Pressure hold test

26

Gas sterilization (2)

-exposure to ethylene oxide gas diluted with an inert gas
-for heat and moisture sensitive material

27

In a gas chamber during sterilization what is controlled? (4)

-temperature
-humidity
-gas concentration
-exposure time

28

Ionizing Radiation Sterilization (2)

-gamma radiation from cobalt-60
-used for medical devices and hospital supplies

29

Sterilization needs to be validated, how is this possible? (4)

-biological indicators
-recording thermocouples
-color change indicators
-melting indicators

30

What does the USP 797 classify CSP as low risk? (2)

-made outside the PEC and is intended for emergency use
-administration must be given no later than 1 hour