Drug Absorption #1 Flashcards Preview

Pharmaceutics Spring 2016 > Drug Absorption #1 > Flashcards

Flashcards in Drug Absorption #1 Deck (29)
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1

biopharmaceutics deals with factors that influence....

bioavailability

2

What factors can affect bioavailability? (4)

-drug
-patient specifically
-form
-route of administration

3

T/F The amount of drug in the blood will effect the amount of drug that gets to the site of action.

TRUE

4

Cmax

the highest concentration achievable from a single dose

5

Tmax

how long from administrations before the maximum concentration is achieved

6

Increased rate?-->>

Cmax: Increase
Tmax: Decrease
AUC: no effected

7

Increased extent?-->

Cmax: Increase
Tmax: no effect
AUC: Increase

8

T/F Cmax and Tmax are usually visually determined

TRUE

9

AUC is determined by using the .....

Trapezoidal rule-->
Area= 1/2 (a +b) * c (sum of the two parallel sides * distance between the sides * 1/2

10

____ is determined using the last two concentration values collected

K el(Elimination constant)

11

K el or elimination is ___ order, so you have to change it to ____

FIRST; log

12

T/F Once the drug is released from the dosage form, it has to be dissolved before it can cross the membrane

TRUE

13

By what mechanism are most drugs given orally absorbed?

passive diffusion

14

Why do we have carriers in the GI tract?

to move nutrients through the membrane (these can not passively move across)

15

Rate of diffusion (dc/dt) determines....

how slow or rapidly the drug moves into the blood

16

P (3)

-partition coefficient
-measure of lipid solubility
-a constant

17

A LARGER P = .....

Higher Lipid solubility

18

Partition coefficient equation

ratio of relative solubility of a drug in lipid (/) relative solubility in water

19

D

diffusion coefficient
-a constant

20

A

area of surface at which diffusion is occurring
-a constant

21

h

thickness of the membrane
-a constant

22

C ad

concentration of drug at the site of administration

23

C p

concentration of drug in the plasma

24

T/F Diffusion is a random process

TRUE

25

Drug diffusing into the blood after being administered is driven by

kinetic energy (random movement of molecules)

26

Direction in which the molecules move depends on.....

the concentration gradient (usually from high to low concentration)

27

Permeability depends on ____ and _____ properties

solute and membrane

28

Drug Absorption is GENERALLY a _____ order process

FIRST

29

Which law can be used to determine the rate of diffusion?

Fisk Law of Diffusion