Flashcards in Transdermal Delivery Deck (21)
Skin is composed of _____ and _____?
outer EPIdermis and inner DERMIS
The is cushioned on what ?
Fatty subcutaneous tissue
The subcutaneous fat layer is also called?
hypodermis and is several mm thick
The structure of the epidermis is made up of what 6 components?
(listed oldest to youngest)
Which layer has keratinocytes and other specialized cells such as melanocytes and langerhans cells?
Which cells are the major antigen-presenting cells of the skin?
What is considered the INNER LAYER of viable cells?
Stratum germinativum (or stratum basale or basal layer)
What is considered the OUTER LAYER of viable cells?
stratum corneum (about 10 μm when dry; 10-15 cell layers), or horny layer
The dermis may be typically ____ thick?
3 to 5 mm
The Dermis (corium) is a matrix of what?
connective tissue with blood vessels, nerves, sweat glands and origin of hair follicles
Sebaceous glands empty into ____ and secrete _____?
- follicles to form PILOSEBACEOUS unit
- sebum which lubricates skin surface and maintains surface and maintains surface pH around 5.0.
What varies from about 50 to 250 follicles per sq. cm. of skin?
What 2 surfaces are hairless?
palmar and plantar surfaces
What are the 2 delivery systems for drugs applied to the skin?
- topical delivery
Which system uses skin as a route of administration for systemic delivery?
Name 4 conventional dermatological formulations.
What are the benefits of oral drug delivery? (2)
-Absence of first pass metabolism
- Sustained effect possible
What are the benefits of IV drug delivery? (2)
-Ease of self administration and termination
What are the benefits of PK drug delivery? (2)
-reduced systemic exposure
-reduced adverse effects
Name the 6 factors that affect percutaneous absorption. ***
1. Drug conc./ solu. in vehicle
2. partition coefficient
3. surface area
4. skin hydration and temp.
5. the site of application
6. penetration enhancers