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Flashcards in Bleeding disorders Deck (37):
1

What kind of infection usually preceded henoch schonlein purpura?

GI infection

2

Wat autoimmune condition causes peripheral platelet destruction?

Immune thrombocytopenic purpura

3

Give three causes of peripheral platelet destruction?

Coagulopathy
Autoimmune
Hypersplenisa

4

Where are platelets broken down?

Spleen

5

What is the most common cause of a platelet function disorder?

Drus - Aspirin, NSAIDs Clopidogrel (Stop platelets aggregating
Renal failure

6

What is the genetic pattern of von willebrand factor deficiency?

Autosomal dominant
Type 1 = low numbers
Type 2 = non functioning von willebrand factor
Type 3 = no von willebrand factor

7

What are the three types of von willebrand factor deficiency?

Type 1 = low numbers
Type 2 = non functioning von willebrand factor
Type 3 = no von willebrand factor

8

If you have no von willebrand factor then what factor will you also be deficient in?

Factor 8

9

What drug is useful for nosebleed etc seen in haemostatic problems?

Transexemic acid = stabilised fibrin clot

10

What factor is missing is haemophilia A?

Factor 8

11

What factor is missing is haemophilia B?

9

12

Where are all clotting factors made?

Liver

13

What is the significance of low albumin in bleeding disorders?

If the albumin low then the liver probably isn't making other clotting factors - liver failure is the most likely underlying cause

14

In multiple factor deficiencies what will the PT and APPT be like?

Both prolonged

15

Which factors are carboxylated by vitamin K?

2, 7, 9 and 10

16

How do you get most of you vitamin K?

Synthesis by intestinal bacteria

17

What are babies injected with just after birth to protect against bleeding?

Vitamin K

18

What is DIC?

Excessive and inappropriate activation of the haemostatic system
(Primary, secondary and fibronolysis)

19

Why do you get end organ failure in DIC?

Microvascular thrmobus formation

20

Why do you get bleeding in DIC?

They have used up all their clotting factors causing

21

If the PT and APPT are both prolonged what is the most likely cause?

Problem with multiple clotting factors

22

Why do you get high D dimer level in DIC?

D dimer levels rise when there is an excess of fibrinolysis, as seen in DIC

23

What is the most common cause of DIC?

Sepsis - meningococcal sepsis

24

Give 4 causes of DIC

Sepsis
Obstetric emergencies

25

What clotting substance is the placenta very high in?

Thromboplastin

26

What does thromboplastin do?

Conversion of prothrombin to thrombin

27

What is the treatment of DIC?

Treat underlying cause

28

What three things can you give in DIC whilst trying to fix the underlying cause?

- Platelets
- Plasma
- Fibrinogen

29

What is the genetic inheritence pattern of haemophiilia?

X linked

30

Which of the haemophillia is more common?

Hameophillia A

31

Why isn't minor trauma a problem to hameophillia?

Platelets are fine - platelet plug formation is normal but formation of a fibrin clot is not.

32

When do you get excess bleeding in hameophelia?

Severe trauma or surgery

33

What vessels are affected mostly in haemophillia?

Medium and Large blood vesses.

34

What is the prothrombin time like in hameophillia?

Normal

35

What is the APPT like in haemophillia?

Very high

36

What is abnormal in haemophillia - PT or APPT?

APPT is very high
PT is normal

37

What is the treatment for haemophillia?

IV factor given every second day