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Flashcards in Clinical Questions/Buzzwords Deck (17):
1

What does the detection of HbS without any HbA indicate in an anaemic patient?

Sickle cell anaemia

2

What does the detection of HbS, where HbA is also present, indicate?

Sickle cell trait

3

What does a disproportionate reduction in MCV compared to haemoglobin levels indicate?

A haemooglobinopathy trait eg Thalassemia

4

What does a disproportionate reduction in MCV compared to haemoglobin levels indicate, with raised HbA2?

Beta thallasemia trait

5

What do you call red cells with a loss of central pallor?

Spherocytes

6

What condition is most likely if a patient has spherocytes on blood film and a family history of haemolytic anaemia?

Hereditary Spherocytosis

7

How do you treat asymptomatic iron deficiency?

Oral iron

8

What is the treatment for autoimmune haemolytic anaemia?

Steroids and folic acid

9

What is the most important diagnostic test to do in a patient who is strongly suspected to have an acute leukemia?

Immunophennyotyping to determine lineage

10

A 58 year old lady with a family history of hypothyroidism and atrophic gastritis presents with fatigue, macrocytosis and pancytopenia.

pernicious anaemia

11

A 25 year old male has recurrent admissions to hospitals with pain in his legs and chest wall. On one occasion, he became extremely breathless and required a red cell exchange transfusion.

Sickle cell anaemia

12

A 21 year old girl has a history of heavy periods and investigations indicate a defect in primary haemostasis. Her blood count is normal

Von Wilebrands disease

13

What is the theraputic target of rituximab?

CD20 (expressed on B cells and B cell lymphomas)

14

What is the theraputic target of imantinib?

Tyrosine Kinase inhibitor than inhibits the BCR - ABL 1 protein seen in chronic myeloid leukemia

15

What is the theraputic target of aspirin?

Irreversible inactivator of cyclooxygenase

16

What does cyclooxygenase do?

required for the production of prostoglandsing and thromboxanes for platelet aggregation

17

A 67 year old man admitted to hospital with back pain, hypercalcemia and renal failure is found to have significant Bence Jones proteinuria.

Multiple Myeloma