Lymphoma Flashcards Preview

Haematology > Lymphoma > Flashcards

Flashcards in Lymphoma Deck (35):
1

What is more common; T or B cell lymphoma?

B cell lymphoma

2

What is more common; Hodgekins or Non Hodgekins?

Non Hodgkins

3

Which type of hodgkins lymphoma is seen in a young people and is predominantely mediastinal involvement?

Nodular sclerosing

4

Which type of hodgkins lymphoma is see in older people and is most commonly involving the inguinal nodes?

Nodular lymphocytic

5

What is the pathopneumonic feature of hodgkins lymphoma or a peripheral blood smear?

Reed Sternberg Cell

6

In which type of lymphoma do you get alcohol induced pain?

Hodgkins lymphoma

7

What is the first line investigation for hodgkins lymphoma?

Lymph node biopsy

8

What types of lymphoma are associated with EBV?

Burkitt's lymphoma
Hodgkins lymphoma

9

What type of lymphoma is associated with HTLV infection?

Adult T cell lymphoma

10

What type of lymphoma is associated with HIV?

Non hodgkins lymphoma

11

list some B cell symptoms?

Fever
Night sweats
Weight loss

12

Are the lymph nodes generally tender in lymphoma?

No

13

After you have found lymohoma on a lymph node biopsy what do you need to do next?

Immunohistochemistry (Looks at patterns of proteins on the surface on cell by using antibodies against these)
Immunophenotyping
Cytogenic analysis - FISH

14

What kind of cells does the lymph node cortex contain?

B cells

15

What kinds of cells does the lymph node paracortex contain?

T cells

16

What is in the medulla of a lymph node?

Cords and sinusoids

17

What is the germinal centre of a lymoh node?

The place where white cells are primed with antigens

18

What type of lymphoma is associated with the MYC translocation?

Burkitts lymphoma

19

Where does a naive B cell from the bone marrow go in the lymph node once it encounters an antigen?

Mantle zone (becomes a mantle cell)
Germinal centre (centroblast then a centrocyte
Marginal zone (marginal zone B cell)
Plasma cell

20

What kind of lymphoma results from naive B cells?

Small lymphocytic B cell NHL

21

What kind of lymphoma results from mantle cells?

Mantle cell B cell NHL

22

What kind of lymphoma results from centroblast cells?

Diffuse large B cell NHL

23

What kind of lymphoma results from centrocytes?

Follicular B cell NHL

24

What kind of lymphoma originates in the marginal zone of the lymph node?

Marginal zone B cell NHL

25

What are the two types of T cell NHL?

Cutaneous T Cell lymphoma (mycosis fungoides)
Enteropathy associated lymphoma (associated with coeliac disease)

26

Which type of lymphoma is associated with coeliac disease?

Enteropathy associated lymphoma

27

What are the three important high grade NHL lymphomas?

Burkitts
Diffuse Large B cell Mantle cell

28

What are the three important low grade NHL lymphomas?

Small lymphocytic
Follicular
Marginal zone

29

What is the chemotheraputic treatment of follicular cell lymphoma?

Anti CD20 (Rituximab)

30

What is the most common symptoms of burkitts lymphoma in children?

Rapidly growing jaw mass

31

What is the cause of waldenstroms macroglobinemia?

Uncontrolled clonal proliferation of terminally differentiated B lymphocytes

32

What mutation is most commonly seen in waldenstroms macroglobinemia?

MYD88

33

Which antibody has proliferated in waldenstroms macroglobinemia?

IgM

34

What kind of cancer is waldenstroms macroglobinemia?

Lymphoplasmacytic lymphoma

35

Which is the most common type of cancer in children?

Acute Lymphoblastic Leukemia