Flashcards in Lymphoma Deck (35):
What is more common; T or B cell lymphoma?
B cell lymphoma
What is more common; Hodgekins or Non Hodgekins?
Which type of hodgkins lymphoma is seen in a young people and is predominantely mediastinal involvement?
Which type of hodgkins lymphoma is see in older people and is most commonly involving the inguinal nodes?
What is the pathopneumonic feature of hodgkins lymphoma or a peripheral blood smear?
Reed Sternberg Cell
In which type of lymphoma do you get alcohol induced pain?
What is the first line investigation for hodgkins lymphoma?
Lymph node biopsy
What types of lymphoma are associated with EBV?
What type of lymphoma is associated with HTLV infection?
Adult T cell lymphoma
What type of lymphoma is associated with HIV?
Non hodgkins lymphoma
list some B cell symptoms?
Are the lymph nodes generally tender in lymphoma?
After you have found lymohoma on a lymph node biopsy what do you need to do next?
Immunohistochemistry (Looks at patterns of proteins on the surface on cell by using antibodies against these)
Cytogenic analysis - FISH
What kind of cells does the lymph node cortex contain?
What kinds of cells does the lymph node paracortex contain?
What is in the medulla of a lymph node?
Cords and sinusoids
What is the germinal centre of a lymoh node?
The place where white cells are primed with antigens
What type of lymphoma is associated with the MYC translocation?
Where does a naive B cell from the bone marrow go in the lymph node once it encounters an antigen?
Mantle zone (becomes a mantle cell)
Germinal centre (centroblast then a centrocyte
Marginal zone (marginal zone B cell)
What kind of lymphoma results from naive B cells?
Small lymphocytic B cell NHL
What kind of lymphoma results from mantle cells?
Mantle cell B cell NHL
What kind of lymphoma results from centroblast cells?
Diffuse large B cell NHL
What kind of lymphoma results from centrocytes?
Follicular B cell NHL
What kind of lymphoma originates in the marginal zone of the lymph node?
Marginal zone B cell NHL
What are the two types of T cell NHL?
Cutaneous T Cell lymphoma (mycosis fungoides)
Enteropathy associated lymphoma (associated with coeliac disease)
Which type of lymphoma is associated with coeliac disease?
Enteropathy associated lymphoma
What are the three important high grade NHL lymphomas?
Diffuse Large B cell Mantle cell
What are the three important low grade NHL lymphomas?
What is the chemotheraputic treatment of follicular cell lymphoma?
Anti CD20 (Rituximab)
What is the most common symptoms of burkitts lymphoma in children?
Rapidly growing jaw mass
What is the cause of waldenstroms macroglobinemia?
Uncontrolled clonal proliferation of terminally differentiated B lymphocytes
What mutation is most commonly seen in waldenstroms macroglobinemia?
Which antibody has proliferated in waldenstroms macroglobinemia?
What kind of cancer is waldenstroms macroglobinemia?