Cytotoxic Drugs Flashcards Preview

Haematology > Cytotoxic Drugs > Flashcards

Flashcards in Cytotoxic Drugs Deck (22):
1

What is the G0 phase of the cell cycle?

Resting

2

What is the G1 phase of the cell cycle?

Starting to grow

3

What is the S phase of the cell cycle and when does it occur?

After 9 - 12hrs. DNA synthesis occurs

4

What is the M stage of the cell cycle?

Cells undergo mitosis

5

In cell cycle specific drugs what is more important; the duration of exposure or the dosage?

Duration of exposure

6

What are the two main groups of cell cycle specific chemotherapy drugs?

Antimetabolites
Mitotic spindle inhibitors

7

In non cell cycle specific agents what is more important; the duration of exposure or the dosage?

Dosage

8

How do alkylating agents such as chlorambucil work as chemotheraputic drugs?

Bind covalently to DNA bases and produce strand breaks by free radical production

9

How do cytotoxic antibiotics such as anthracyclines work as chemotheraputic drugs?

Reversible DNA intercalation impairs RNA transcription and causes strand breakages in DNA

10

What are the general side effects of cytotoxic drugs and why?

They affect rapidly dividing organs
- Bone marrow suppression
- Gut mucosal damage
- Hair loss

11

What is the specific side effect of vinca alkaloids?

Neuropathy

12

What is the specific side effects of anthracyclines?

Cardiotoxicity

13

What is the specific side effects of cisplatinum?

Nephrotoxicity

14

Which drugs are most likely to cause infertility?

Alkylating agents

15

What two structures can chemotherapy not pass through?

Blood brain barrier
Blood testes barrier

16

What prophylactic antifungal drugs are given to all people at risk of fungal infections due to chemotherapy?

Itraconazole
Posaconazole

17

What is rituximab?

Monoclonal antibody against CD20. CD 20 is primarily found on the surface of B cells. Rituximab destroys these B ce;;s and so in used in leukemias and lymphomas.

18

What is the protein expressed on Hodgekins cells? What drug targets this protein?

CD 30. Bretuximab

19

Why are biological drugs not classed as chemotherapy?

They do not affect the cells as they divide.

20

What is the function of the proteosome in a cell?

Degrade unneeded or damaged proteins

21

Why are proteosome inhibitor uses in cancer treatment?

May prevent breakdown of proteins such as p53

22

If you get an allogenic bone marrow transplant what donor cells attack the cancer in the host?

T cells (Graft vs leukemia/lymphoma)