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Flashcards in Haemopoiesis Deck (19):
1

What is the lifespan of neutrophils?

7 - 8 hours

2

What is the life span of a platelet?

7 - 10 days

3

What is the life span of a RBC?

120 days

4

Where do you usually find megakaryocytes?

Bone marrow

5

What do megakaryocytes differentiate into?

Platelets

6

What is the precursor cell for platelets?

Megakaryocytes

7

What is a myelocytes?

An intermediate nucleated precursor cell between neutrophils and blast cells?

8

What is meant by a "blast cell"

A nucleated precursor cell

9

What embryological layer are haemopoetic stem cells derived from?

Mesoderm

10

What is the first site of haemopoeisis in the embryo?

Yolk sac

11

What three organs perform haemopoiesis in the fetus?

Liver
Spleen
Bone marrow

12

What is the most common site of bone marrow biopsy in an adult?

Iliac crests

13

What is the name given to the interface between the bone marrow and the bone?

Endosteum

14

What are sinusoids in the bone?

Speciailised venules that form a reticular network of denestrated vessels. They regulat the passage os cell in and out of the circulation

15

What is meant by red bone marrow?

Haemopoitically actove marrow

16

What is meant by yellow bone marrow?

Fatty inactive marrow

17

What is meant by the myeloid erthyroid ratio?

relationship of neutrophils and precursors to proportion of nucleated red cell precursors (ranges from 1.5:1 to 3.3:1) – can change (eg reversal in haemolysis as a compensatory response)

18

What kind of cells does bone marrow aspirate look for?

Precursor cells

19

What three tests could you do to look for rare cell populations in haemopoiesis?

Immunophenotyping
Cytochemistry
Clonogenic assays