Breast Pathology Flashcards Preview

D&T 4 exam 1 > Breast Pathology > Flashcards

Flashcards in Breast Pathology Deck (40):
1

epithelium layer of nipple and areola, what does it change into while entering breast?

- stratified squamous
- double layer cuboidal

2

breast development at menarche

terminal ducts give rise to lobules and increased interlobular stroma

3

breast development in follicular phase

lobules quescient

4

breast development in luteal phase

cell proliferation with increased acini/lobule

5

breast development in pregnancy

breast assumes complete morphologic and functional maturity

6

Milk line remnants

persistence of epidermal thickening along milk line

7

Accessory axillary breast tissue

mastectomy may not remove all breast tissue

8

congenital inversion of nipple

nursing difficulties and can be confused with inversion due to carcinoma or inflammation

9

macromastia

severe back pain

10

reconstruction or augmentation

formation of capsule with inflammatory response causing cosmetic deformity and difficulty in mammographic evaluation

11

what are the 3 most common symptoms of breast disease

1. pain
2. palpable mass
3. nipple discharge

12

what are 2 principal signs for mammographic screening

1. densities
2. calcifications

13

who is vulnerable to acute mastitis

nursing breasts

14

what is the most common cause of acute mastitis

staph aureus
less common - strep

15

treatment for acute mastitis

drainage and antibiotic

16

Periductal mastitis

painful eythermatous subareolar mass

17

who is most likely to get periductal mastitis

smokers

18

what is histo for periductal mastitis

keratinizing squamous extends
-keratin accumulates dilating and rupturing duct

19

treatment for periductal mastitis? problems

- incision and drainage
- does not remove squamous epithelium which can cause recurrence
-remove duct and fistulous tract

20

who does mammary duct ectasia occur in

5th to 6th decade in multiparous women

21

how does mammary duct ectasia present

poorly defined mass, skin retraction, cheesy discharge

22

what is the morphology of mammary duct ectasia

- periductal and interstitial chronic granulomatous inflammation

23

what are 3 incidences that can cause fat necrosis

trauma
prior surgical intervention
radiation therapy

24

gross morphology for fat necrosis ? early and late?

early: hemorrhage
late: liquefaction necrosis

25

histo for fat necrosis

central necrotic fat cells surrounded by lipid laden macrophages and intense neutrophilic infiltrate

26

etiology for granulomatous mastitis

- systemic granulomatous disease (wegner's)
- infections

27

morphology gross for granulomatous mastitis

granulomas in lobular epithelium

28

who gets granulomatous mastitis

- parous women

29

what is lymphocytic mastopathy

hard palpable masses
- collagenized stroma surrounding atrophic ducts and lobules

30

what are 3 groups for benign epithelial lesions

1. non-proliferative
2. proliferative
3. atypical hyperplasia

31

what can cause non-proliferative breast changes

hormonal imbalance
- increase estrogen OR
-decreased progesterone

32

what are 3 patterns seen in non-proliferative breast changes

1. cyst formation
2. fibrosis
3. adenosis

33

unopened cysts in non-proliferative breast changes lookl ike what

"blue dome cyst"

34

non-proliferative breast changes the cysts can cause what metaplasia

aprocrine metaplasia

35

apocrine metaplasia

lining cells have abundant eosinophilic cytoplasm resemebling sweat glands

36

what causes fibrosis in non-proliferative breast changes

rupture of cyst and release of contents resulting in inflammation

37

what is adenosis

increase in number of acinar units per lobule
-calcifications can be seen

38

what is it called if lumens enlarged in adenosis

blunt duct adenosis

39

What is proliferative breast disease without atypia

proliferation of ductal epithelium and/or stroma without cellular abnormalities suggestive of malignancy

40

What are 5 parts of proliferative breast disease without atypia

1 epithelial hyperplasia
2. sclerosing adenosis
3. complex sclerosing lesion (radial scar)
4. papillomas
5. fibroadenomas