The Endocrine System: pituitary - Graffeo Flashcards Preview

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Flashcards in The Endocrine System: pituitary - Graffeo Deck (47)
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1

name hormones secreted by anterior pituitary

- GH
-ACTH
- TSH
-FH
-LH
- PRL

2

name hormones secreted by posterior pituitary

ADH
OT ( oxytocin)

3

from what embryology does ant. pituitary come from

- oral ectoderm
- Rathke's pouch Stem cell

4

which part of the pituitary has the infundibular stalk

posterior pituitary

5

which pituitary has a venous/portal system

anterior pituitary

6

pituitary sits in what bone structe

sella turcica
- depression in sphenoid bone

7

what is the post. pituitary derived from

nervous system tissue

8

what are 3 types of cells found in normal anterior pituitary and what do they secrete

Acidophil: GH, PRL
Basophil: ACTH, LH, FSH
Chromophobe: TSH

9

the hypothalamus produces 2 hormones that have a negative impact on what pituitary hormones

dopamine --> prolactin
GIH somatostatin --> GH

10

majority of cases of hyperpituitarism is due to what

adenomas

11

How is pituitary adenoma classified

hormone produced, usually one, can be multiple

12

who can get pituitary adenoma

all adults

13

pituitary ademona is associated with what neoplasm

multiple endocrine neoplasia MEN-1

14

What can cause pituitary adenoma?

mass effect of Sella turcica

15

what are 3 effects of pituitary adenoma

- visual field abnormalities - bitemporal hemianopsia
- ICP
- hypopituitarism

16

what can be seen in histo for pituitary adenoma

- red or blue or no stain
- no reticulin network

17

atypical adenomas have increased what

- mitotic figures
- increased KI67

18

what is the most common hyper functioning pituitary adenoma

prolactinoma

19

what do prolactinoma form

- calcify and from psammoma bodies
- pituitary stone

20

signs and symptoms for prolactinoma

- amenorrhea, galactorrhea, infertility
- loss of libido (men)

21

what are physiologic causes of serum hyper-prolactinemia

pregnancy
nursing
stress

22

how does stalk effect create a serum hyper-prolactinemia

- mass in suprasellar compartment
- interferes with normal inhibition by hypothalamus to release dopamine to inhibit PRL secretion

23

name 2 drugs that decrease serum prolactinemia

phenothizines
haloperidol

24

does a mild elevation in prolactin in patient with adenoma mean prolactin-secreting tumor

no

25

how is prolactinoma treated? first line?

- dopamine agonists
- Bromocriptine - first line
- Transphenoidal surgery

26

what is the second most common adenoma

growth hormone

27

is GH adenoma acidophilic or chromophobic

acidophilic

28

signs and symptoms for GH adenoma

Pre-pubertal children: gigantism
adults: acromegaly

29

GH adenoma patients have increased risk for what

GI cancers

30

are corticotroph adenomas basophilic or chromophobic

basophilic