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Flashcards in OCP Deck (77)
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1

where is most estrogen produced?

ovaries

2

who makes estrogen in premenopausal women

granulosa cells or fetoplacental unit during pregnancy

3

what is the predominant estrogen type in postmenopausal women

estrone

4

where is estrone made

liver and adipose tissue

5

what is the most potent estrogen

17beta-estradiol

6

rank the potency of estrogens from strongest to weakest

1. 17beta-estradiol
2. estrone
3. estiol

7

all gonadal hormones are synthesized from what

cholesterol

8

what converts androstenedione or testosterone to steroidal estrogens

aromatization of the A ring - catalyzed by aromatase

9

what estrogens does the placenta make and how?

estrone and estriol
DHEA

10

all 3 estrogens are excreted how from body

along with glucuronide and sulfate conjugates

11

estrogen impact on ovaries

- stimulate follicular growth
- too much , atrophy of ovaries

12

estrogen impact on uterus

endometrial growth

13

estrogen impact on vagina

- cornification of epithelial cells
- thickening and stratification of epithelium

14

estrogen impact on cervix

- increase cervical mucous
- lowers viscosity ( favors sperm access)

15

estrogen impact on cholestrol

hypocholesterolemic effect

16

estrogen impact on electrolytes

retention of Na, Cl and water by kidney

17

where is progesterone secreted

corpus luteum
adrenal cortex
testis

18

once fertilization occurs what hormone is secreted

hCG

19

during 2nd and 3rd month of pregnancy what does the placenta secrete

E2 and P

20

name 3 actions of progestrone

1. development of secretory endometrium
2. increase viscosity
3. maintain pregnancy

21

what happens to the women body when progesterone levels decline

menstruation

22

how is GnRh, FSH, and LH secreted. what phase are they secreted in

GnRH: intermittent
FSH and LH: pulsatile

Follicular phase

23

both LH and FSH stimulate what in the follicular phase

Graafian follicle growth

24

FSH by it self stimulates what in the follicular phase

maturation and estrogen production
by granulose cells

25

What are estrogen effects on pituitary during early follicular phase

inhibitory

26

What are estrogen effects on pituitary during midcycle follicular phase

positive

27

what is essential for ovulation

LH surge

28

what follows LH surge

follicle rupture within 24-48 hours

29

progesterone is under influence of what hormone

LH

30

what are 3 therapeutic uses for estrogen and progestins

contraception
postmenopausal hormone therapy