Women's Reproductive System - Carpenter Flashcards Preview

D&T 4 exam 1 > Women's Reproductive System - Carpenter > Flashcards

Flashcards in Women's Reproductive System - Carpenter Deck (105):
1

What is the epithelium of ectocervical mucosa

squamous
non-keratinizing

2

What is the epithelium of endocervical mucosa

Columnar cells
- mucin

3

Another name for cervis

transformation zone

4

epithelium of cervix

squamocolumnar junction

5

what are 2 layers of uterus

myometrium
endometirum

6

histo for fallopian tubes

- columnar, both ciliated and non-ciliated
- intercalated cells (peg cells)

7

what female structures does herpes simplex invade

vulva
vagina
cervix

8

what does HSV look like

painful, red papules on vulva
- vesicles, ulcers

9

For diagnosis what can detect HSV

NAA - nucleic acid amplification
Pap smear
detect anti-HSV antibodies

10

what does herpes look like on pap smear

ground glass nuclei

11

What is Molluscum contagiosum

pox virus

12

what does Molluscum contagiosum impact

skin and mucous membranes

13

What Molluscum Contagiosum is most prevalent

MCV1

14

What Molluscum Contagiosum is sexually transmitted

MCV2

15

Molluscum commonly occurs in who

young children 2-12

16

how is Molluscum transmitted in children

1 direct contact
2. inaminate objects
3. lesion of trunk, arms, legs

17

how is Molluscum transmitted in adults

sexually

18

Clinical appearance of Molluscum

papules
dome-shaped
dimpled center

19

what does Molluscum look like under microscope

Intracytoplasmic viral inclusions

20

What is most common yeast infection

Candida

21

What are risk factors for candida

pregnancy
diabetes
BCP

22

symptoms of yeast infections ( candida)

itching
erythema
cottage cheese-like discharge

23

What is used to diagnose yeast infection ( candida)

pap smear
wet preparation
culture and/or NAA

24

What does Candida look like on pap smear

"spaghetti and meatballs"

25

clinical feature of Trichomonas vaginalis

fishy vaginal discharge with fishy odor

26

Trichomonas vaginalis can cause what

inflammatory response

27

what is the gross appearance of Trichomonas vaginalis

strawberry cervix

28

Trichomonas vaginalis increase susceptibility to what disease

HIV

29

What is the impact of Trichomonas vaginalis on pregnancy

- preterm deliver
- low birth weight infants

30

What is the easiest method to diagnose trichomonas? other methods

wet prep ( easiest)
- pap smear
- liquid pap vial

31

What are characteristic of gardnerella

gram negative small bacillus

32

what CAN gardnerella be associated with?

bacterial vaginitis

33

on a wet prep or pap smear what do you seen for Gardnerella

epithelial cells covered with bacteria
-- Clue cells

34

Chlamydia trachomatis causes what 3 diseases

1. follicular cervicitis
2. endometritis
3. salpho-oophoritis

35

what is follicular cervicitis

abundant lymphocytes seen infiltrating cervix

36

chlamydia trachomatis can cuase what

infertility

37

how is chlamydia trachomatis diagnosed

pap smear by NAA test
urine specimen

38

Name 3 agents that can cause pelvic inflammatory disease

1. gonorrhea
2. chlamydia
3. enteric bacteria

39

what are 3 clinical features of pelvic inflammatory disease

1. pelvic pain
2. fever
3. vaginal discharge

40

When does PID occur

following: abortion, D&C, surgical procedure, normal delivery

41

what is puerperal infection

any bacterial infection of the female reproductive tract following childbirth or miscarriage.

42

initially what does PID cause

- acute suppurative salpingitis
-- acute inflammatory cells filling tubes
-- cause abscess formation

43

where does gonococcal PID usually begin? what anatomy does it involve? where can it spread and when does this happen? What layer does it involve

Bartholin glands
- cervix
2-7 days after exposure
- upward to tubes and ovaries
surface epithelium

44

How does non-gonococcal PID spread?

lymphvascular channels

45

What is the difference between gonococcal and non-gonococcal PID

non-gonococcal: inflammatory reaction deeper in layers
gonococcal: surface epithelium

46

what are 3 complications of PID

1. peritonitis
2. bacteremia
3. intestinal obstruction

47

on what anatomical structure does leukoplakia occur

vulva

48

what does leukoplakia look like

"white plaque"

49

how is leukoplakia diagnosed

biopsy

50

what is lichen sclerosis

white patches with associated labial atrophy
- can be pruritic
- multiple areas

51

who is lichen sclerosis seen in?

post menopausal

52

what can cause lichen simplex chronicus

rubbing skin to relieve pruritis

53

what can lichen simplex chronicus present as

leukoplakia

54

What is the histo for lichen simplex chronicus and lichen sclerosis

lichen simplex chronicus: acanthosis, hyperkeratosis
lichen sclerosis: thin epidermis, decrease glands

55

acanthosis

thickening of epidermis

56

what is condyloma acuminatum

venereal wart
benign condition

57

Condyloma Acuminatum is associated with what other problem

HPV types 6 and 11 (low risk)

58

what is seen microscopically for Condyloma Acuminatum

kiolocyte (halo cell)

59

Majority of vulvar carcinomas are what type of carcinomas

squamous cell carcinomas

60

how are vulvar carcinomas categorized

HPV related
non-HPV related

61

what is HPV related vulvar carcinoma called

Basaloid/Warty carcinioma

62

basaloid/warty carcinoma is associated with high risk of what

HPV

63

what is Basaloid/warty carcinoma preceded by

VIN

64

how can Basaloid warty carcinoma initially appear as

leukoplakia

65

what type of women get non-HPV related vulvar carcinoma

with long standing lichen sclerosis or squamous cell hyperplasia

66

what is histo for non-HPV vulvar carcinoma

keratinizing squamous cell cancers

67

what disease is vulvar squamous cell carcinoma associated with and precedes it

HPV
VIN

68

grossly what does extra mammary paget disease look like

pruritic red crusted lesions

69

histo for extra mammary paget disease

large tumor cells surrounded by clear halos

70

where does paget disease originate from? where does the disease usually stay

stem cells or apocrine ducts
epithelium

71

Breast Paget disease 100% associated with

adenocarcinoma

72

vaginal carcinomas are what type majority

squamous cell carcioma

73

vaginal carcinoma is associated with what disease

HPV

74

how does one usually get vaginal carcinoma

spread from cervical lesion

75

Why was Diethylstibesterol given to women

prevent preterm delivery

76

what is the problem with DES

problems with daughter
not much problems with son

77

DES increases risk for what

- clear cell adenocarcinoma
- structural abnormalities of female genital tract
- infertility

78

how does vaginal adenosis from DES change epithelium

squamous epithelium replaced by glandular epithelium

79

who is embryonal rhabdomyosarcoma/sarcoma botryoides seen in

children less than 5 years

80

embryonal rhabdomyosarcoma/sarcoma botryoides gross appearance

grapelike clusters projecting from vagina

81

what is the process of cervix squamous metaplasia

1. increase estrogen increases glycgoen uptake by cervical/vaginal mucosa
2. glycogen provides substrate for bacteria
3. bacteria causes drop in vaginal pH
4. endocervix responds by proliferation of reserve cells
5. metaplasia

82

cervical squamous metaplasia is very susceptible to what infection

HPV

83

is squamous metaplasia normal

yes

84

is endocervical polyp begign

yes

85

what can cause endocervical polyp

vaginal discharge, bleeding

86

what is seen under microscope for endocervical polyp

mucinous columnar epithelium
thick-walled vessels

87

cervical condyloma is associated with what

HPV 6, 11 (low risk)

88

cervical cancer is associated with what

HPV 16, 18

89

risk factors for cervical cancer

- early age intercourse
- multiple sex partners
- smoking
-OCP
- male with multiple partners

90

what type of HPV do adolescents get

HPV 16

91

if a women is negative for HPV, she has low risk for development of what

cervical cancer

92

CIN3 classification dysplaisa?

severe dysplasia/CIS
high risk HPV

93

what area does HPV infect

immature squamous metaplastic cells, transformation zone
- not mature squamous cells ( vagina, vulva)

94

can a virgin get HPV

yes

95

HPV encodes what viral proteins

E6/E7

96

E6/E7 interact with what

Rb
p53

97

is cervical intraepithelial neoplasia cancerous? what is it

no,
precancerous dysplasia

98

what is the dysplasia classification for CIN1

mild dysplasia
- low grade

99

e dysplasia classification for CIN2

moderate dysplasia

100

what is seen under microscope for dysplasia

nuclear atypia
increased nuclear/cytoplasmic ratio
koilocytosis

101

CIN 1 where do changes occur

lower 1/3 of epidermis

102

where do CIN2 changes occur

lower 2/3 of epidermis

103

where do CIN 3 changes occur

entire layer

104

What are 3 types of cervical squamous cell carcinoma

fungating
ulcerating
infiltrative

105

cervical Adenocarcinoma comes from what layer

endocervical epithelium