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D&T 4 exam 1 > Diabetic drugs > Flashcards

Flashcards in Diabetic drugs Deck (27):
1

name 3 things released from Beta cells of pancreas

insulin
C-peptide
Amylin

2

Insulin is stored as secretory granule in what form

hexamer

3

what is the biologically active form of insulin

monomer

4

Insulin release requires what from the beta cells

increased intracellular calcium

5

a rise in plasma glucose increases what ratio

ATP/ADP

6

increase ATP in beta cell causes what

- close K channel
- depolarization
- influx voltage-dependent Ca channel

7

what is the principal stimulus for insulin? best route of administration

glucose
better response with oral

8

What beta agonist can stimulate inuslin

isoproterenol

9

name 4 substances what will inhibit insulin release

Diazoxide
somatostatin
alpha2-agonist
beta2-antagonist

10

what are the different parts of insulin receptor

alpha and beta

11

Name the rapid insulin analgouges

aspart
glulisine
lispro

12

what rapid insulin analogue is absorbed the fastest? when is it injected? How is it injected

aspart
- 5 min before meal
- sub-cutaneous, IV

13

which short acting insulin is compatible only with NPH insulin in syringe? compatible only with NPH insulin?

Lispro and gluilisine
aspart

14

Name long acting insuline

Determir
Glargine

15

Determir biochemical arrangement

B30 amino acid threonine omitted and a 14 carbon fatty acid is attached to the
B29 amino acid.

16

What is onset of Gargine

-Onset in 1 hr but constant response

17

fever, hyperthyroidism, surgery, trauma, infection does what to insulin

increase insulin requirements

18

nausea/ vomiting; hypothyroidism, renal impairment, liver impairment does what to insulin

Decreased insulin requirements

19

most common adverse effects of insuline

hypoglycemia

20

PRAMLINTIDE MOA

Synthetic amylin analog. Amylin released with insulin by βeta cells.

21

Pramlintide use and how do you take the drug

Approved for Type 1 and 2 diabetics
Injected sc

22

Pramlintide

1. Hypoglycemia – severe
2. Never mix with insulin in same syringe
3. DO not use in diabetic with gastroparesis

23

SULPHONYLUREAS
1. MECHANISM OF ACTION OF SULPHONYLUREAS

Stimulate insulin release
-Binds to cell surface receptor

24

Chlorpropamide, Tolbutamide

1st generation of sulphonylureas

25

Glimepiride, Glyburide

2st generation of sulphonylureas

26

Sulphonylureas uses

a. Type II Diabetes who are ketosis resistant

c. Central Diabetes Insipidus
Chlorpropamide in patients who cannot tolerate desmopressin

27

Sulphonylureas contrandications

a. Hypoglycemia
b. Contraindication ketoacidosis must use insulin
c. Chlorpropamide