Chapter 26 - Narcotic, Antagonists, and Antimigraine Agents Flashcards Preview

Nur 30 Pharmacology > Chapter 26 - Narcotic, Antagonists, and Antimigraine Agents > Flashcards

Flashcards in Chapter 26 - Narcotic, Antagonists, and Antimigraine Agents Deck (10):

Morphine (I)

Narcotic Agonist

Relief of moderate to severe acute or chronic pain; preoperative medication; component of combination therapy for severe chronic pain, intraspinal to reduce intractable pain


Morphine (A)

Acts as an agonist at specific opioid receptors in the CNS to produce analgesia, euphoria, and sedation


Morphine (CI)

CI- diarrhea caused by toxic poisons, biliary surgery or surgical anastomoses, respiratory dysfunction, GI or GU surgery, head injuries, alcoholism, delirium tremens, , cerebral vascular disease, liver or renal dysfunction, and during labor


Morphine (AE)

AE- ureteral spasm, respiratory and circulatory depression, apnea, respiratory arrest


Naloxone (I-A)

Indi- Complete or partial reversal of narcotic depression; diagnosis of suspected opioid overdose

Action- Pure narcotic antagonist; reverses the effects of the opioids, including respiratory depression, sedation, and hypotension


Naloxone (AE-CI)

AE- Acute narcotic abstinence syndrome (n/v, sweating tachycardia, fall in blood pressure)

CI- narcotic addiction, CV disease, prego and lactation


Ergotamine (I-A)

Ergot Derivative

I- Prevention or abortion of vascular headaches

A- Constricts cranial blood vessels, decreases pulsation of cranial arteries, and decreases hyperperfusion of the basilar artery vascular bed; mechanism of action is not understood


Ergotamine (CI-DD-AE)

AE- tingling of the fingers and toes, muscle pain in the extremities, pulselessnessor weakness in the legs, precordial distress, ergotism.

CI- CAD, HTN, or peripheral vascular disease, impaired liver,, prego and lact, Ergotism, pruritus, malnutrition

DDI- beta blockers


Sumatriptan (I - A)


I-Treatment of acute migraine; treatment of cluster headaches (subcu route)

A- Binds to serotonin receptors to cause vasoconstrictive effects on cranial blood vessels


Sumatriptan (AE-CI-DD)

AE- vertigo, myalgia, BP alterations, tightness or pressure on chest, burning sensation

CI- active CAD, caution w/ elderly patients, and renal and hepatic dysfunction, and prego and lact

DDI- ergot-containing drugs, use only 2 weeks after done using MAIO