Clinical aspects of lipids Flashcards Preview

Cardio > Clinical aspects of lipids > Flashcards

Flashcards in Clinical aspects of lipids Deck (16)
Loading flashcards...
1

Situations when you should measure lipids?

-MI, CVA, other vascular disease
-Acute pancreatitis
-Family history
-Clinical signs

2

Main treatment options for lipids?

Statins
Others= PCSK9 inhibitors, ezetimibe, fibrates

3

Describe a lipid?

-All lipids are fats
-Low solubility in water
-Biochemically very diverse

4

Key lipids?

Cholesterol

5

How are you likely to come across lipids?

Fatty deposits in tendons - xanthomata
Xanthelasma- fatty deposits around eyes
Corneal arcus
Milky blood/serum

6

What we measure in practice?

Total cholesterol
HDL cholesterol
Triglycerides as requested
Calculate total HDL cholesterol ratio
LDL cholesterol calculated as requested

7

What should balance of HDL and LDL be?

More LDL than HDL

8

Lipid hypothesis essentially?

That having too much lipid in your blood is a risk factor for CVD?

9

Why are statins important?

They lower cholesterol but they also inhibit the atherosclerotic mechanism and can sometimes reduce the atherosclerosis in arteries

10

Statins that you will come across?

Prevastatin
Simvastatin
Atorvastatin
Rosuvastatin
Fluvastatin

11

Examples of PCSK9 inhibitors?

Alirocumab
Evolocumab

12

Classes of lipid medications

Statins
PCSK9 Inhibitors
Fibrates
*something else)

13

Simvastatin summary

Lots of evidence that it reduces mortality
Efficacy isn't the best

14

Pravastatin summary

Isn't really prescribed

15

Atorvastatin summary?

One of the most commonly prescribed

16

Fluvastatin summary?

Weakest statin and therefore the safest