Flashcards in Common Cardiovascular Drugs Deck (112)
PCSK 9 Inhibitors
Examples of statins?
Examples of PCSK 9 inhibitors?
What does PCSK stand for?
Proprotein convertase subtilisin/kexin type 9
Examples of vasodilators?
Angiotensin Receptor blockers
When are patients given fibrates fro high cholesterol?
When they can't tolerate statins
What do statins do?
Blocks HMG Co-A reductase
What is HMG Co-A Reductase?
rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.
What are statins used in?
Stroke/Mini stroke (CVA/TIA)
High risk of- MI/CVA
Side effects of statins?
Rhabdomyolysis - renal failure
Disease where muscle fibers do not function properly- cause muscle spasms and muscular weakness
Rhabdomyolysis is the breakdown of damaged skeletal muscle. Muscle breakdown causes the release of myoglobin into the bloodstream. ... If you have too much myoglobin in your blood, it can cause kidney damage.
Example of a fibrate?
What are fibrates used in?
Low HDL cholesterol
Symptoms of hypercholesterolemia?
Xanthomas- fatty deposits around tendons
Cholesterol deposits around eyes
What is used to treat familial hypercholesteroleamia?
PCSK 9 Inhibitors- alirocumba, evolocumab
How does PCSK- 9 inhibitor work?
By inhibiting the binding of PCSK 9 to LDLR, it increases the number of LDLRs available to clear LDL, thereby lowering LDL-C levels.
LDLR= low density lipoprotein receptors
What can high BP cause if not treated?
Stroke, aterioschlerosis, kidney failure, heart attack/heart failure, blindness
What do Diuretics do?
Block Na+ reabsorption in kidneys
What are thiazide diuretics sued for?
Mild hypertension eg bendrofluazide
Which is stronger loop diuretics or thiazide?
What are loop diuretics used for?
example of one-Furosemide
Side effects of diuretics?
Increased uric acid= gout
What do beta blockers do?
Block B1 &B2 adrenoceptors
What do cardioselective beta blockers do?
Only block Beta 1 receptors
What are cardioselective beta blockers used in?
Acute coronary syndrome
What do non-selective B blockers do?
Block B1 and B2 receptors
Examples of non selective beta blockers
carvedilol (alpha and beta blocker)