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Flashcards in Common Cardiovascular Drugs Deck (112)
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1

Anti-cholesterol Drugs?

Statins
Fibrates
PCSK 9 Inhibitors

2

Examples of statins?

Simvastatin
Atorvastatin

3

Examples of PCSK 9 inhibitors?

Ecolocumab,
Alirocumab

4

What does PCSK stand for?

Proprotein convertase subtilisin/kexin type 9

5

Anti-hypertensive drugs?

Thiazide diueretics
Beta blockers
Vasodilators

6

Examples of vasodilators?

Calcium antagonists
Alpha blockers
ACE inhibitors
Angiotensin Receptor blockers

7

When are patients given fibrates fro high cholesterol?

When they can't tolerate statins

8

What do statins do?

Blocks HMG Co-A reductase

9

What is HMG Co-A Reductase?

rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.

10

What are statins used in?

Hypercholesterolaemia
Diabetes
Angina/MI
Stroke/Mini stroke (CVA/TIA)
High risk of- MI/CVA

11

Side effects of statins?

Myopathy
Rhabdomyolysis - renal failure

12

Myopthay

Disease where muscle fibers do not function properly- cause muscle spasms and muscular weakness

13

Rhabdomyolysis

Rhabdomyolysis is the breakdown of damaged skeletal muscle. Muscle breakdown causes the release of myoglobin into the bloodstream. ... If you have too much myoglobin in your blood, it can cause kidney damage.

14

Example of a fibrate?

Bezafibrate

15

What are fibrates used in?

Hypertriglyceridaemia
Low HDL cholesterol

16

Symptoms of hypercholesterolemia?

Xanthomas- fatty deposits around tendons
Cholesterol deposits around eyes

17

What is used to treat familial hypercholesteroleamia?

PCSK 9 Inhibitors- alirocumba, evolocumab

18

How does PCSK- 9 inhibitor work?

By inhibiting the binding of PCSK 9 to LDLR, it increases the number of LDLRs available to clear LDL, thereby lowering LDL-C levels.
LDLR= low density lipoprotein receptors

19

What can high BP cause if not treated?

Stroke, aterioschlerosis, kidney failure, heart attack/heart failure, blindness

20

What do Diuretics do?

Block Na+ reabsorption in kidneys

21

What are thiazide diuretics sued for?

Mild hypertension eg bendrofluazide

22

Which is stronger loop diuretics or thiazide?

Loop

23

What are loop diuretics used for?

Heart failure
example of one-Furosemide

24

Side effects of diuretics?

Hypokalaemia (tired)
Arrhythmias
Hyperglycaemia (diabetes)
Increased uric acid= gout
Impotence

25

What do beta blockers do?

Block B1 &B2 adrenoceptors

26

What do cardioselective beta blockers do?

Only block Beta 1 receptors

27

What are cardioselective beta blockers used in?

Angina
Acute coronary syndrome
Myocardial infarction
Hypertension
Heart failure

28

What do non-selective B blockers do?

Block B1 and B2 receptors

29

Examples of non selective beta blockers

Propranolol
carvedilol (alpha and beta blocker)

30

Examples of cardioselective B blockers?

Atenolol
Bisoprolol