Flashcards in Gender differences in heart disease Deck (23)
Number 1 killer of women?
What does HFpEF stand for?
Heart failure with preserved ejection fraction
What is HFpEF?
No proven treatment
Associated with poor quality of life an depression
Underdetected due to lack of biomarker and tests
Lifetime risk of developing CAD in women?
Men have more risk of getting MI and re-infarctions. True or flase?
False. Women are more likely to get it
Reasons for worse cardiovascular outcomes in women?
Atypical and delayed presentation and diagnosis
Lack of awareness of risk and symptoms in women
Assessment bias- less likely to get referrals
Biological bias- gender differences in drug responses and vessel sizes
Higher procedural complication rates
Structural features of CAD in women?
Increased stiffness of vessel (fibrosis remodeling)
More diffuse disease
In younger women-
More plaque obstruction less obstructive disease coronary dissection
Functional features of CAD in women?
Smooth muscle dysfunction
Pathophysiology of IHD in women?
Hypertension, hyperlipidemia, obesity
Positive coronary remodelling + Abnormal coronary reactivity
Positive coronary remodelling?
Increased wall thickness, plaque erosion, distal embolization
Abnormal coronary reactivity?
Statistics of woman who get chest pain in a heart attack?
Symptoms which both men and women get in heart attacks?
Atypical symptoms (but typical in women)
-Milder symptoms (without chest pain) normally in younger women
-Shortness of breath
-Sudden onset of weakness
-Fatigue, body aches or overall feeling of illness
-Unusual feeling of mild discomfort in back, arm, chest, neck or jaw
-Heartburn, nausea, vomiting, abdominal pain
-Symptoms may occur up to a week before MI- fatigue, sleep disturbance, SOB, anxiety, indigestion, palpitations
Types of risk factors in women for Atherosclerotic Cardiovascular Disease?
Non modifiable risk factors for Atherosclerotic Cardiovascular Disease?
Modifiable risk factors for Atherosclerotic Cardiovascular Disease?
Obesity and overweight
Emerging risk factors for Atherosclerotic Cardiovascular Disease?
Hypertensive disorders of pregnancy
______increases risk of heart disease __ fold regardless of ___.
____ doubles the risk of a second heart attack in ____ but not in ____.
What does hypertensive disease in pregnancy and pre- eclampsia increase risk of?
High blood pressure
Female specific risk factors fro CVD?
Autoimmune conditions- rheumatoid arthritis
Depression- other forms of mental stress
Low socioeconomic status