Flashcards in Colorectal cancer Deck (15):
What are the risk factors for colorectal cancer?
Previous adenoma or colorectal cancer
Lack of exercise
How do most colorectal cancers arise?
Pre-existing colorectal polyps
What is the origin of adenoma polyps?
What are the 2 min histological types of adenomas?
What is the morphology of adenoma polyps?
How does colorectal cancer present?
Altered bowel opening
Iron deficiency anaemia
Palpable rectal or right lower abdominal mass
Acute colonic obstruction
What are the investigations of colorectal cancer?
Colonoscopy (retrieve tissue biopsy, polypectomy)
What are the risks of colonoscopy?
What is the pathway progression of Duke's classification?
A= tumour confined to mucosa
B= tumour extended through mucosa to muscle layer
C= involvement of lymph nodes
D= distant metastatic disease
What is the treatment for colorectal cancer?
Radiotherapy (rectal only)
What is the palliative treatment for colorectal cancer?
What test is used to screen the population for colorectal cancer?
FOB (faecal occult blood ) test
What are the high risk groups that must be screened?
Inflammatory bowel disease
Heritable conditions (familial adenomatous polyposis, hereditary non polyposis colorectal cancer)
What is familial adenomatous polyposis?
Autosomal dominant condition
Mutation of APC gene on chromosome 5
Caan get desmoid tumours or extracolic manifestations