Flashcards in Inflammatory Bowel Disease Deck (23):
What are the 2 types of IBD?
What causes IBD?
Environmental trigger or genetically susceptible people
Symptoms of UC?
What is ulcerative colitis?
Continous inflammation which only affects the colon. It starts in the rectum and works proximally
What are the clinical features of UC?
>6 stools/day with blood
What is Crohn's?
Patchy inflammation affecting mouth to anus with skip lesions. Can cause ulcers, strictures and fibrosis
What are the symptoms of Crohn's?
What are the clinical features of Crohn's?
High ESR and CRP
High platelet count
What are the main histological differences between UC and Crohn's?
UC is transmural
Crohn's will have non caveating granulomas
More crypt abscesses in UC
Goblet cells depleted in UC
What extra-intestinal manifestations could occur in IBD?
Liver and biliary tree
What disease can present very similarly to Crohn's?
What disease is associated with UC?
What method is used to continue surveillance of IBD?
What drugs are aminosalicylates (5ASA)?
Pro drugs (Balsalazide, Olzalazide, Sulfasalazide)
How are 5ASA used in UC?
Reduces number and severity of relapses
Reduces CRC risk
How is 5ASA used in Crohn's
Used for Crohn'd colitis
What steroids are used in IBD?
Prednisolone (40mg per day then tapering reduction)
What thiopurine is used in IBD?
Azathioprine (Side effects incl leucopenia, pancreatitis and hepatotoxicity)
How is methotrexate used in IBD?
Unlicensed use in Crohn's
Requires specialist follow up
Name some immunosuppressants used in IBD?
What are the Anti-TNF alpha antibodies in IBD treatment called?
Infliximab (8 weekly infusions)
Adulimumab (bi weekly SC injections)
What is the alpha4b7 intern blocker used in IBD called?