Flashcards in Pathology of Upper GI Tract Deck (11):
What is the pathology of oesophageal reflux?
Thickening of squamous epithelium
Ulceration of oesophagus
What are the pathological complications of oesophageal reflux?
Healing by fibrosis causes strictures, impaired motility and obstruction
What change does the epithelium undergo in Barrett's oesophagus?
Transformation from squamous to glandular epithelium
What is metaplasia?
Transformation of a normal type of tissue to another normal type of tissue
What are the local pathological effects of oesophageal cancer?
What are the pathways of oesophageal cancer spread?
Direct to surrounding structures
Lymphatic spread to regional lymph nodes
What are the 3 different pathological types of gastritis?
What is the pathological pathway of autoimmune gastritis?
Atrophy of specialised acid secreting gastric epithelium
Loss of specialised gastric epithelial cells
Decreased acid secretion
Loss of intrinsic factor
What is the pathological pathway of bacterial gastritis?
Helicobacter pylori found in gastric mucus on epithelium
Produces acute and chronic inflammatory response
Increased acid production
What causes chemical gastritis?