Pathology of Upper GI Tract Flashcards Preview

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Flashcards in Pathology of Upper GI Tract Deck (11):
1

What is the pathology of oesophageal reflux?

Thickening of squamous epithelium
Ulceration of oesophagus

2

What are the pathological complications of oesophageal reflux?

Healing by fibrosis causes strictures, impaired motility and obstruction

3

What change does the epithelium undergo in Barrett's oesophagus?

Transformation from squamous to glandular epithelium

4

What is metaplasia?

Transformation of a normal type of tissue to another normal type of tissue

5

What are the local pathological effects of oesophageal cancer?

Obstruction
Ulceration
Perforation

6

What are the pathways of oesophageal cancer spread?

Direct to surrounding structures
Lymphatic spread to regional lymph nodes
Blood spread

7

What are the 3 different pathological types of gastritis?

Autoimmune
Bacterial
Chemical injury

8

What is the pathological pathway of autoimmune gastritis?

Atrophy of specialised acid secreting gastric epithelium
Loss of specialised gastric epithelial cells
Decreased acid secretion
Loss of intrinsic factor

9

What is the pathological pathway of bacterial gastritis?

Helicobacter pylori found in gastric mucus on epithelium
Produces acute and chronic inflammatory response
Increased acid production

10

What causes chemical gastritis?

NSAIDS
Alcohol
Bile reflux

11

What is the pathological process behind peptic ulceration?

Imbalance between acid secretion and mucosal barrier
Increased gastric acid