Constipation Flashcards

1
Q

_____is the difficult passage of small hard

stools

A

Constipation

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2
Q

ROME Criteria for constipation

duration:

to be positive, fulfill?

A

12 weeks

> 2

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3
Q

ROME III Criteria

• infrequent passage of stools 25% of time
• sensation of incomplete evacuation >25% of time
• use of manual manoeuvres >25% of time
• sensation of ________
>25% of time

A

3/week

straining

anorectal obstruction/blockage

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4
Q

emphasis should be on the
_______rather than on the frequency
of defecation;

A

consistency of the stool

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5
Q

Constipation from infancy may be due to

_____

A

Hirschsprung disorder

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6
Q

______is the single most important factor in

preventing constipation

A

Diet

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7
Q

Unusually shaped stools (small pellets or ribbonlike)

suggest _____

A

irritable bowel syndrome

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8
Q

The ________ is far superior to the
rigid sigmoidoscope in investigation of the lower
bowel

A

flexible sigmoidoscope

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9
Q

MC cause of constipation

A

The commonest is ‘idiopathic’ constipation where
there is no structural or systemic disease. This is also
referred to as ‘functional’ constipation

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10
Q

Alarm Sx for constipation

A
  • Recent constipation in >40 years of age
  • Rectal bleeding
  • Family history of cancer
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11
Q

In the Mx of constipation,

Ensure that the anthraquinone group of
laxatives, including_____, is never used
long term because they cause melanosis coli and
associated megacolon

A

‘Ford pills’

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12
Q

Three of the primary masquerades
are important causes of constipation, namely
______

A

drugs, depression and hypothyroidism

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13
Q

These drugs may be associated with
constipation, especially codeine and its derivatives,
___, ____ and ______

A

antidepressants, aluminium and calcium antacids

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14
Q

The metabolic causes of constipation include
1
2
3

A

hypothyroidism, hypercalcaemia and porphyria

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15
Q

Diabetes rarely can be associated with constipation
when an _______ can lead to
alternating bouts of constipation and diarrhoea.

A

autonomic neuropathy

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16
Q

Constipation may be a manifestation of an underlying
functional problem and psychiatric disorder, such
as
1
2
3
4

A

depression, anorexia nervosa, schizophrenia or

drug abuse

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17
Q

It is worth noting that 60% of polyps and
cancers will occur in the _______
and diverticular disorder should be evident with the
flexible sigmoidoscope

A

first 60 cm of the bowel

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18
Q

The presence of _____is an important
sign—it may give a pointer to the duration of the
constipation and the consequent chronic intake
(perhaps denied) of anthraquinone laxatives

A

melanosis coli

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19
Q

Labs for constipation work-up. What blood chem?

A

— thyroid function tests
— serum calcium
— serum potassium
— carcinoembryonic antigen (a tumour marker)

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20
Q
Radiological findings 
— CT colonography (virtual colonography)
—\_\_\_\_\_\_\_\_\_ (especially for
primary colonic disease, e.g. megacolon)
— \_\_\_\_\_\_\_\_, using radio-opaque
shapes taken orally and checking progress by
abdominal X-ray or stool collection
A

double contrast barium enema

bowel transit studies

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21
Q

Physiological tests:

— \_\_\_\_\_\_\_\_—test anal tone
— rectal sensation and compliance, using an
\_\_\_\_\_\_\_\_\_
— \_\_\_\_\_\_\_\_\_, to determine
disorders of defecation
— Rectal biopsy, to determine \_\_\_\_\_\_
A

anal manometry

inflatable rectal balloon

dynamic proctography

aganglionia

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22
Q

__________or faecal incontinence is the

inappropriate passage of normal stool

A

encopresis

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23
Q

constipation is difficulty or delay in passing the
stool with incomplete emptying of the rectum:
this can present as _______, due to faecal retention
with overflow of liquid faeces (paradoxical
diarrhoea)

24
Q

consider if stool hard and associated with pain or

bleedin

A

Anal fissure in infants

25
It is best to classify idiopathic constipation into three subgroups: 1 2 3
1 simple constipation 2 slow transit constipation 3 normal transit constipation (irritable bowel syndrome)
26
______or lazy bowel, is the term used to describe a rectum that has become unresponsive to faecal content, and this usually follows repeated ignoring of calls to defecate
Dyschezia,
27
Pharma Tx of constipation An appropriate choice would be one of the hydrophilic bulk-forming agents such as ____
ispaghula or | psyllium.
28
What to avoid in the tx of constipation
Avoid stimulant laxatives except for short | sharp treatments.
29
Stimulant (irritant) laxatives examples
Sodium picosulfate Anthraquinones: senna (Senokot/Sennetabs), senna with dried fruits (Nu-Lax), sennosides A and B; cascara Frangula bark (in Normacol Plus) Castor oil Triphenylmethanes: bisacodyl (e.g. Dulcolax); picsulfate
30
CX of fecal impaction
Complications include spurious diarrhoea, faecal incontinence, bowel obstruction, urinary incontinence or retention
31
Tx of fecal impaction
Treat with oral or osmotic laxatives (e.g. 8 sachets of macrogol 3350 for 3 days with or without rectal suppositories) or enema e.g. Fleet Enema, Microlax.
32
• Commonest GIT malignancy • Second most common cause of death from cancer in Western society • Generally men over 50 years (90% of all cases)
Colorectal cancer
33
Prognosis of colon CA
Good prognosis if diagnosed early
34
location of Colon CA
Two-thirds in descending colon and rectum
35
RF for colon CA
• Ulcerative colitis (long-standing) • Familial: familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal cancer • Colonic adenomata • Decreased dietary fibre
36
Why is DRE impt in rectal CA
this is appropriate because many cancers are found in the lowest 12 cm and most can be reached by the examining finger
37
Cx of rectal CA in the rectum
If obstructing, there is a risk of rupture of the caecum.
38
Spread of colon CA * Lymphatics → _______ * Direct → _________ * Blood → ______
epigastric and para-aortic nodes peritoneum portal circulation
39
Dx of choice for colon CA
CT colonography (investigation of choice)
40
Serum_____is not useful for diagnosis but is | useful for monitoring response to treatment
CEA level
41
_____ (if available) is useful for follow-up
PET scanning
42
If FOBT is positive—investigate by ____ or ____
colonoscopy | or by flexible sigmoidoscopy
43
An FOBT every_____ years is now recommended for all | people from 50 years
2
44
Colonoscopy recommendation for moderate risk COlon CA
• Moderate risk: every five years from 50 years or 10 years younger than when a family member presented
45
Colonoscopy reco for high risk
• High risk: guided by clinical genetics team but as a rule yearly or 2 yearly commencing at 25 years, and every 12 months from 12–15 years of age if a strong family history of FAP.
46
Criteria used for colorectal CA
Modified Dukes’ classification of colorectal | cancer
47
What is Modified Dukes’ classification of colorectal cancer A B C D
A: Cancer limited to mucosa and submucosa B. Cancer extends into muscularis or serosa C. Cancer involves regional lymph nodes D. Distant metastases (e.g. liver
48
5 year SR of diff stages of colon CA A B C D
88 70 43 7
49
ff up pts with colon CA
* CEA antigen * colonoscopy * abdominal imaging: ultrasound or CT scan of liver
50
DRE of Hirschprung
Rectal examination—narrow or normal rectum
51
Dx of Hirschprung Abdominal X-ray/barium enema—_____
distended | colon full of faeces to narrow rectum
52
Dx of Hirschprung Absent rectoanal reflex on ______
anal manometry
53
Tx of Hirschprung
Resect narrow segment after preliminary colostomy
54
``` • In older children and adults • Mainly due to bad habit • Can be caused by: — chronic laxative abuse — milder form of Hirschsprung disorder — Chagas disease (Latin America) 2 — hypothyroidism (cretinism) — systemic sclerosis ```
Acquired megacolon
55
DRE of acquired megacolon
Rectal examination—dilate loaded rectum, lax | sphincter
56
First-line treatment of functional constipation (unresponsive to simple measures) is _______. An _______ is good second-line therapy.
a bulking agent osmotic laxative
57
Beware of ______ causing constipation in | the elderly patient on diuretic treatment
hypokalaemia