Dermatologic Pharmacology Flashcards Preview

D & T exam 2 > Dermatologic Pharmacology > Flashcards

Flashcards in Dermatologic Pharmacology Deck (16):
1

Percutaneous absorption is what kind of absorption process

diffusion process

2

What layer of the epidermis is the rate limiting step for percutaneous absorption

stratum corneum

3

In Fick's law what directly increases M drug amount in receptor phase

D - diffusion constant
C - concentration of donor drug

4

In Fick's law what has an inverse relationship with M - drug amount in receptor phase

h - skin thickness

5

Diffusion laws: what increases J - amount of drug penetrating

Km- solubility
Dm - diffusion coefficient

6

Diffusion laws: what decreases J - amount of drug penetrating

Th - thickness of skin

7

diseased or non-intact skin has what effects

increase percutaneous absorption
decrease transepidermal water loss

8

in what time in you life do you have the greatest skin permeability

preterm infant
aged skin more permeable

9

shunt diffusion

transient and small amount of substances diffuse through hair follicles and eccrine glands

10

where is the highest rate of drug penetration

- scrotum, post-auricular, eyelid, scalp, soles, palms
- body folds
- diffusion shunts

11

what does temperature effect absorption

increase temperature increase diffusion

12

how does increasing hydration of s. corneum effect percutaneous absorption? This concept can treat what?

increases
- inflammatory skin disease

13

what does hydration do the blood vessels

vasoconstriction

14

which one has greater absorption
1. high concentration of 1 dose
2. equally divided doses of lesser concentration

1.

15

tachyphylasxis

rapidly diminishing response to successive doses of a drug, rendering it less effective.

16

long term use of steroid application can lead to what

Tachyphylaxis