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Flashcards in Bones 2 Deck (52):
1

osteoma defect where on bone

subperiosteal or endosteal cortex surface

2

what type of bone is impacted with osteoma

woven and lamellar bone

3

what is gardner syndrome

multiple osteomas

4

compare sizes of osteoid and osteoblastoma

osteoid: less than 2 cm
osteoblastoma: greater than 2 cm

5

can NSAIDS be used for relief of osteoid and osteoblastoma

osteoid: yes
osteoblastoma: no ``

6

most common nonhematopoetic malignant primary bone tumor

osteosarcoma

7

what is made in osteosarcoma?

osteoid
-painful enlarging mass

8

what age groups are impacted by osteosarcoma

75% less than 20
elderly

9

osteosarcoma is associated with what disease

paget's disease

10

what is Codman triangle

osteosarcoma tumor lifts periostium

11

where does osteosarcoma usally occur on bone

metaphysis medulla, knee

12

osteosarcoma: hereditary retinoblastoma is a defect in what gene

RB

13

osteosarcoma: Li-Fraumeni syndrome defect in

p53

14

osteosarcoma metastazies where

lung

15

Osteochondroma exostosis what happens

mushroom-shaped cartilage-capped

16

where does Osteochondroma exostosis occur

metaphysis: near growth plate of long tubular bones, especially around knee

17

Osteochondroma exostosis: multple heredity exotosis isa defect in what gene and how is passed on

EXT1 and EXT2
autosomal dominant

18

how fast does osteochondrom grow? pain? increases risk for what

slow growing, stops with closure of growth plate
- Multiple Hereditary exostosis

19

Chondroma is what

benign hyaline cartilage tumor

20

where is enchondroma

phalynx

21

where does subperiotsteal chondroma occur

surface of bone

22

what does enchondroma look like

less than 3cm grey-blue
nodules of hyaline cartilage with peripheral enchondral ossification

23

enchondroma is a risk of turning into

Enchondromatosis ( Ollier disease)
Maffucci syndrome: enchondromas with hemangiomas

24

most common place for enchondroma tumor

phalynx

25

chondroblastoma is seen in what age group

teenagers

26

chondroblastoma most common place found where on body

KNEE EPIPHYSIS

27

define chondrosarcoma

no malignant bone formation

28

where does chondrosarcoma occur

intramedullary
juxtacortical and surface

29

histo of chondrosarcoma

clear cell
differentiated
mesynchymal

30

what are the 3 patterns for fibrous dyspasia

monostotic
-polystotic with soft tissue myxomas
- polyostotic with endocrine dysfunction

31

what does the X-ray look like for fibrous dysplasia

ground glass and well-demarcated

32

where on bone does fibrous dysplasia occur

diaphysis

33

fibrous dysplasia: monostatic where does it usually occur? who does it occur in

ribs femur tibia
teens

34

fibrous dysplasia: polyostatic, is what two diseases

Mazabraud syndrome
McCune-Albright syndrome

35

fibrous dysplasia: McCune-Albright syndrome? clinical presentaiotn
endocrine?

cafe au lait skin pigmentations
sexual precocity, hyperthyroidism

36

fibrous dysplasia histo

chinese character woven bone in fibrous stroma

37

what is Ewing Sarcoma family

small round blue cell tumor of bone and soft tissue

38

gene translocation for ewing sarcoma

T(11;22)
EWS-FLI1

39

Ewing occurs where in bone

medullary cavitity but invades cortex into soft tissue
- dipahysis of long bone

40

other symptoms with Ewing

fever, anemia, leukocytosis

41

what is giant cell tumor of bone

benign locally aggressive tumor of macrophage/monocyte system

42

mononuclear cells have what receptor

RANKL

43

where on bone does giant cell tumor occur

epiphysis may extend to metaphysis

44

most common location of ewing

knee

45

Aneurysmal bone cyst (ABC)

multiloculated blood-filled cysts

46

where does Aneurysmal bone cyst (ABC) occur

metaphysis of long bones and vertebrae

47

most common form of skeletal malignancy

metastatic disease

48

how can metastatic disease spread to bone

direct
lymph or hematogenous
-intraspinal ( batson plexus of veins)

49

bone tumors of metaphysis

osteoid osteoma
osteochondroma
osteosarcoma
chondroma
fibrous dysplasia
fibrous cortical defect
ABC

50

bone tumor on epiphysis

clear cell chondrosarcoma
chondroblastoma

51

bone tumor on diaphysis

ewing sarcoma
firbous dysplaisa

52

bone tumor on epiphysis/metaphysis

giant cell tumor aneurysmal bone cyst