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Flashcards in Joints Deck (59):
1

what is osteoarthritis

degenerative joint disease

2

cause of primary osteoarthritis

idiopathic
aging

3

secondary osteoarthritis

repeated injury
obesity

4

what happens to cartilage in osteoarthritis

degeneration of cartilage
-superficial roughened and cracked cartilage
-joint mice ( loose bodies of cartilage )

5

what are 3 phases of osteoarthritis

chondrocyte injury
chondrocytes proliferate
chondrocyte drop out with loss of cartilage

6

what happens to the bone in osteoarthritis

bone spurs
bone eburnation (exposed bone on surface)

7

what are some symptoms of osteoarthtitis

worse with use
crepitios of joint
morning stiffness

8

what nodes and where are found in osteoarthritis

Heberden nodes: Osteophytes at DIP in women

9

what joints does osteoarthritis spare

wrist elbow and shoulders

10

Rheumatoid arthritis

systemic autoimmune inflammatory disease

11

what gender is more prone to rheumatoid arthritis

females

12

what is formed in Rheumatoid arthritis

Pannus: exuberant inflamed synovium

13

what get eroded with Rheumatoid arthritis

cartilage and bone

14

in rheumatoid arthritis 80% have what

rheumatoid factor: autoAb against Fc portion or IgG

15

in Rheumatoid arthritis the Ab attaches to what part of antigen

citrullin-modified peptides

16

what is the synovial fluid content for Rheumatoid arthritis

high protein content

17

how and where does Rheumatoid arthritis present in joints

symmetrical
PIP, MCP, MTP,
wrists, ankles, elbow, knees

18

what makes Rheumatoid arthritis better

activity

19

what are the hand deviations for rheumatoid arthritis

radial deviation of wrist
ulnar deviation of fingers
flexion-hyperextension of fingers ( swan neck; boutonniere)

20

Rheumatoid arthritis, what cysts are found in the back of the knee

synovial cysts
baker cysts

21

clinically what make rhematoid arthritis differenct from osteoarthrisits

RA: no DIP
rheumatoid nodules

22

juvenile idiopathic arthritis

before age 16
knees, wrists, elbows, ankles

23

how are juvenile idiopathic arthritis and Rheumaoid arthritis the same

pannus formation

24

Seronegative Spondyloarthropathies

pathology in ligamentous attachements
immune mediated
HLA B27

25

who gets Seronegative Spondyloarthropathies

young adults
more males

26

what joints are impacted with Seronegative Spondyloarthropathies

axial joints
-sacroiliac joint
-apophyseal joint of vertebra

27

how does spine show up as in X-ray for Seronegative Spondyloarthropathes

bamboos spine

28

another name for reactive arthritis

reiter syndrome

29

what is reactive arthritis

appendicular noninfectious arthritis

30

what bacteria can cause reactive arthritis

Chlamydia
shigella
salmonella

31

what is the triad symptoms for reactive arthritis

arthritis
urethritis
conjunctivitis

32

Reiter syndrome is related to what protein

HLA B27

33

what joints does Reiter syndrome get? characteristics

ankles, knees, fees
asymmetric pattern
symptoms wax and wane

34

Enteritis associated arthrits is associatd with what bacteria

Yersinia, Salmonella, Shigella

35

what joints does enteritis associated arthritis occur in and when does it clear

knee, and ankles
less than a year

36

Psoratic arthritis associated with what protien

HLA B27

37

Psoratic arthritis occurs in what joints

DIP of hand ( pencil in cup)
large joints

38

Psoratic arthritis is histologically similar to what other arthritisi

rheumatoid arthritis

39

what bacteria causes adolescent/young adult infectious arthritis

Gonorrhea

40

what bacteria causeselderly and children infectious arthritis

Staph. Aureus

41

what bacteria causes infectious arthritis in sickle cell anemia

Salmonella

42

if a person abuses drugs, where is the infectious arthritis most likely to occur

axial joints

43

if a person has Gonorrhea, where is the infectious arthritis most likely to occur

knee, hip, shoulder, elbow

44

where does infectious arthritis occur for lyme disease

knees, shoulders, elbows, ankles

45

what is gout

uric acid from purine matabolism

46

tophi

mass deposits of urates

47

characterize the crystals of gout

negative birefringent

48

what causes secondary gout and what does it lead to

nucleic acid turnover
chronic renal disease

49

calcium pryophosphate crystal deposition disease also called

pseudogout

50

where are crystals first seen is pseudogout

articular matrix, menisci, intervertbral disc

51

characterize the crystals for gout

positive birefringent

52

where is ganglion cyst most common? where is it in relation to joint? what degernates

wrist
- no communcation with joint space
-myxoid or cystic

53

where is synovial cyst located in relation to joint? name a type of synovial cyst

- connected to joint capsule or bursa
-baker cyst

54

Tenosynoival giant cell tumor is what translocaion

t(1;2)

55

what are different types of tenosynovial giant cell tumors

diffuse
localized

56

what cells are involved in tenosynovial giant-cell tumor

macrophages, gaint cells

57

Difuse Tenosynoival giant cell tumor is called

pigemnted villonodular synovitis

58

Diffuse Tenosynoival giant cell tumor location

knee

59

Localized Tenosynoival giant cell tumor is attached to what and location

synovium or tendon
- fingers and wrist