Dexmedetomidine Flashcards Preview

Pharm Oral Drugs > Dexmedetomidine > Flashcards

Flashcards in Dexmedetomidine Deck (10):
1

class

non-barbiturate induction agent

2

structure

imadazole derivative

3

mech of action

alpha 2 agonist - decreases NE release presynaptically causing sedation, anxiolysis, analgesia
produces hypnosis in the locus cerelus

4

pharacokinetics
PB
LS
Vd
elimination

PB 90%
low lipid solubility
Vd: 3L/kg
elimination: conjugated in liver, excreted in urine/bile

5

onset
doa
T1/2

onset: rapid, distributes in 6 minutes
doa: 5-8 min
T1/2: 2-3 hrs

6

active metabolite

none

7

side effects

decrease CBF
NO CHANGE to CMRO2 & ICP

decrease SVR, BP, HR, SNS response

small decrease TV, minimal change RR

potentiates effects of opioids
decreases thermoregulation

8

contraindications

afib, HB, severe brady, hypotension

9

other

can build tolerance
mimics sleep
inhibits CYP450

10

dose

1 mcg/kg over 15 min bolus, then 0.2-1 mcg/kg/hr