Propofol Flashcards Preview

Pharm Oral Drugs > Propofol > Flashcards

Flashcards in Propofol Deck (11):
1

class

non-barbiturate induction agent

2

structure

2,6 di-isopropophenol

3

mech of action

discourages dissociation of GABA from GABA-A receptor, increasing Cl- conduction, hyperpolarizes cell, resists depolarization
inhibits glutamate at the NMDA receptor

4

pharmacokinetics
PB
LS
Vd

highly PB
lipid soluble
Vd: 3.5-4.5 L/kg

5

elimination

metabolized by CYP450, excreted in urine
clearance faster than HBF, extrahepatic metabolism

6

onset
doa
T1/2

onset: 30 sec
doa: 2-8 min
T1/2 0.5-1.5 hr

7

active metabolite

none

8

side effects

decreases CBF, CMRO2, ICP
isoelectric EEG

severe drop in SVR, BP
NO CHANGE to HR

dose dependent decreased RR, TV
bronchodilation
myoclonus

9

contraindications

soy, egg allergy
hypovolemia
caution with elderly

10

other

burning on injection
anti-emetic at low dose
generic propofol-sodium metabisulfite causes bronchospasms

11

dose

induction: 1-2.5 mg/kg IV
sedation: 25-100 mcg/kg/min
maintenance: 100-300 mcg/kg/min
antiemetic 10-20 mg IV