Ketamine Flashcards Preview

Pharm Oral Drugs > Ketamine > Flashcards

Flashcards in Ketamine Deck (10):
1

class

non-barbiturate induction agent

2

structure

phenylcyline derivative (PCP)

3

mech of action

blocks NMDA receptor, decreases ion influx and neurotransmission.
opioid receptor agonist
muscarinic antagonist

4

pharmacokinetics
PB
LS
Vd

PB: 12%
highly lipid soluble, crosses BBB
Vd: 3 L/kg

5

elimination

metabolized by CYP450 to norketamine, hydrolized and conjugated to water soluble compound, excreted by urine.
some eliminated unchanged in urine/feces
hepatic blood flow alters clearance

6

onset
doa
T1/2

onset: 30 sec
doa: 10 min
T1/2: 2-3 hrs

7

active metabolite

Norketamine (20-30% active)

8

side effects

INCREASED CBF, CMRO2, ICP, IOP
emergence delirium
hallucinations
myoclonus
increased SNS response b/c it inhibits NE uptake
increased SVR, BP, HR
direct myocardial depressant

bronchodilation
increased saliva

potentiates NMB

9

contraindications

psych disorders
head/eye injury/surgery
CAD
HTN/PHTN
pheochromocytoma

10

dose

induction: 0.5-2 mg/kg IV
sedation: 0.2-0.5 mg/kg/hr
maintenance 1-2 mg/kg/hr IV; 5-10 mg/kg IM/PR