Lorazepam Flashcards Preview

Pharm Oral Drugs > Lorazepam > Flashcards

Flashcards in Lorazepam Deck (10):
1

Class

Benzo

2

Structure

Benzene ring fused w/ 7 member diazepine ring

3

mech of action

potentiates binding of GABA to the GABA-A receptor, keeping the Cl- channels open and hyperpolarizing the cell, making it resistant to excitation

4

pharmacokinetics
PB
LS
Vd
Elimination

80% PB
highly LS
0.8-1.3 L/Kg Vd
elimination - CYP450 and excreted in urine

5

Onset
DOA
T1/2

onset 20-30 min
DOA -
T1/2 - 10-20 hrs

6

Active metabolite

none

7

Side effects

decrease CBF, CMRO2
no isoelectric eeg
preserves CO2 response
DOES NOT flatten CO2 curve
does not attenuate response to DVL
neuroprotective
can cause paradoxical excitation
decrease SVR, BP, CO with induction dose

decrease RR and TV with opioids

8

Contraindications

decrease dose with hepatic/renal patients
caution with elderly
synergistic with opioids
DO NOT give with glaucoma

9

Other

most potent benzo
pain on injection (propylene glycol)
does not effect NMB

10

dose

pre-med: 1-4 mg IV; 50 mcg/kg PO