Endrophonium Flashcards Preview

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Flashcards in Endrophonium Deck (10):
1

class

reversal; anticholinesterase

2

structure

quanternary ammonium
does not cross BBB

3

mech of action

reversible H+ binding to the acetylcholinesterases forming an electrostatic attachment and increase the amt of ACh at the NMJ

4

LS
Vd

LS: low
Vd: 1 L/kg

5

onset
doa
T1/2

onset: rapid, peak 1-2 min
doa: 30-60 min
T1/2: 110 min

6

elimination

75% excreted by kidneys unchanged
25% hepatic metabolism

7

side effects

decreased SVR, BP, HR

bronchoconstriction
increased saliva, gastric secretions

8

active metabolite

none

9

dose

0.5-1 mg/kg
administer with atropine 0.01 mg/kg

10

contraindications

renal failure will increase doa
GI/GU obstruction
asthma
use with caution in CAD