Neostigmine Flashcards Preview

Pharm Oral Drugs > Neostigmine > Flashcards

Flashcards in Neostigmine Deck (10):
1

Class

reversal, anticholinesterase

2

structure

quanternary ammonia
does not cross bbb

3

mech of action

covalently binds to the carbamyl group of the acetylcholinesterases, inhibiting the breakdown of AcH in the NMJ and increases the availability of ACh at the motor end plate

4

PB
LS
VD

PB low
LS low
VD: 1L/kg

5

elimination

plasma and liver esterases and excreted 50% unchanged in urine

6

active metabolite

3-hydroxyphenyltrimethylammonium
1/10th as potent

7

side effects

decrease SVR, BP, HR

bronchoconstriction
increase saliva
increase gastric secretion
seizures

8

contraindications

renal failure: increased doa
GI/GU obstruction
asthma
use with caution in CAD

9

dose

0.04 - 0.07 mg/kg
administrate with glyco 0.01 mg/kg

10

onset
DOA
T1/2

onset: 3-5 min
DOA: 1 hr
T1/2: 70-80 min