Flumazenil Flashcards Preview

Pharm Oral Drugs > Flumazenil > Flashcards

Flashcards in Flumazenil Deck (11)
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1
Q

Brand name

A

Romazicon

2
Q

class

A

benzo antagonist/reversal

3
Q

Structure

A

imadazobenzodiazepam derivative

4
Q

Mech of Action

A

Competes with benzos for binding sites on GABA-A receptor, reversing their effect. high affinity for receptor

5
Q

pharmacokinetics
PB
Vd
elimination

A

Pb - 50%
Vd - 0.5 L/Kg
elimination - metabolized by liver and excreted by urine

6
Q

Onset
DOA
T1/2

A

onset - 1-2 min
DOA - 30-60 min
T1/2 - 1 hr

7
Q

active metabolite

A

none

8
Q

side effects

A

dizzy, sweating, agitation
depression, confusion, abnormal vision
N/V

9
Q

contraindications

A

DO NOT USE in seizure disorder

hypersensitivity

10
Q

other

A

given to reverse respiratory depression and cardiac effects

11
Q

dose

A

0.2 mg IV, wait 2 min then repeat 0.1 mg q 60 sec to max of 3 mg