Flumazenil Flashcards Preview

Pharm Oral Drugs > Flumazenil > Flashcards

Flashcards in Flumazenil Deck (11):
1

Brand name

Romazicon

2

class

benzo antagonist/reversal

3

Structure

imadazobenzodiazepam derivative

4

Mech of Action

Competes with benzos for binding sites on GABA-A receptor, reversing their effect. high affinity for receptor

5

pharmacokinetics
PB
Vd
elimination

Pb - 50%
Vd - 0.5 L/Kg
elimination - metabolized by liver and excreted by urine

6

Onset
DOA
T1/2

onset - 1-2 min
DOA - 30-60 min
T1/2 - 1 hr

7

active metabolite

none

8

side effects

dizzy, sweating, agitation
depression, confusion, abnormal vision
N/V

9

contraindications

DO NOT USE in seizure disorder
hypersensitivity

10

other

given to reverse respiratory depression and cardiac effects

11

dose

0.2 mg IV, wait 2 min then repeat 0.1 mg q 60 sec to max of 3 mg