Pyridostygmine Flashcards Preview

Pharm Oral Drugs > Pyridostygmine > Flashcards

Flashcards in Pyridostygmine Deck (10):
1

class

reversal; anticholinesterase

2

structure

quaternary ammonia
does not cross BBB

3

mech of action

covalently binds to the carbamyl group of the acetylcholinesterases, inhibiting the breakdown of ACh in the NMJ and increasing the availability of ACh at the motor end plate

4

LS
Vd

LS: low
Vd: 1 L/kg

5

active metabolite

none

6

elimination

70-90% excreted by kidneys;
25% metabolized by hepatic microsomal enzyme system

7

side effects

decreased SVR, BP, HR

bronchoconstriction
increased saliva, gastric secretions

8

contraindications

renal failure with increased doa
GI/GU obstruction
asthma
use with caution in CAD

9

onset
DOA
T1/2

onset: 16 min
DOA: 75 min
T1/2: 112 min

10

dose

100-300 mcg/kg
administer with glyco 0.01 mg/kg
PO 60 mg