Etomidate Flashcards Preview

Pharm Oral Drugs > Etomidate > Flashcards

Flashcards in Etomidate Deck (10):
1

class

non-barbiturate induction agent

2

structure

carboxylated imadazole derivative

3

mech of action

mimics GABA at GABA-A receptors AND increases affinity for GABA to GABA-A receptors. increases Cl- conduction, hyperpolarizes cell, resists depolarization

4

pharmacokinetics
PB
LS
Vd

PB: 75%
lipid soluble at physiologic pH
Vd: 2.5-4.5 L/kg

5

elimination

liver hydrolysis by CYP450 and metabolized by plasma esterases
excreted in urine/bile
hepatic blood flow alters clearance

6

onset
doa
T1/2

onset: 1 min
doa: ??
T1/2: 3-5 hrs

7

side effects

decreases CBF, CMRO2, ICP
anticonvulsant, BUT can cause seizures in pts with hx
CARDIAC STABLE
enhances NMB
30-40% N/V
myoclonus
hiccups
adrenocorticoid suppression for 4-8 hrs

8

contraindications

seizures, porphyria, addision's disease

9

dose

induction: 0.2-0.6 mg/kg IV
sedation: 5-8 mcg/kg/min
maintenance: 10 mcg/kg/min

10

active metabolite

none