Physostygmine Flashcards Preview

Pharm Oral Drugs > Physostygmine > Flashcards

Flashcards in Physostygmine Deck (10):
1

class

anticholinestersae

2

structure

tertiary amine
crosses BBB and GI tract

3

mech of action

forms a carbamyl ester complex at the esteratic site of the enzyme, decreasing ACh metabolism and increasing levels at the NMJ

4

Vd

1 L/kg

5

elimination

hydrolyzed at its ester linkage by cholinesterases and renal excretion is minimal

6

onset
doa
T1/2

onset: 5 min
doa: 0.5-5 hr
T1/2: 15-40 min

7

side effects

decreases SVR, BP, HR

bronchoconstriction
increases saliva, gastric secretion

8

contraindications

GI/GU obstruction
caution with cardiovascular disease
depolarizing NMB

9

other

can be used for OD of:
atropine
scopalomine
IA
benzos
opioids
barbs

10

dose

15-60 mcg/kg for treatment of contral anti-cholinergic syndrome
may need repeat q 1-2 hr