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Flashcards in DNA flash Deck (18)
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1

Dideoxynucleosides

Anti-retroviral, no 2' or 3' OH. Terminates chain. Reverse transcription inbitiors (anti-retroviral)

2

Combivir

anti-retroviral drug that uses AZT and 3TC

3

AZT

dideoxynucleoside

4

3TC

dideoxynucleoside

5

DNA template read

3'-->5'

6

New strand is made

5'-->3'

7

DNA Primase

DNA-dependent-RNA-pol. That adds RNA primer

8

DNA pol. 3

Prokaryotic pol. That synthesises new strands, does DNA MMR

9

DNA pol. 1

Both direction exonuclease activity

10

All prokaryotic pol.

Polymerize 5-->3 and exonuclease 3'-->5' (check previous nucleotide before adding new)

11

Topoisomerase

enzyme that cuts DNA strands to allow rotation to release tension

12

Quinolones

Drug that targets bacterial topoisomerase, leading to cell death

13

Etoposide

Eukaryotic topoisomerase inhibitors that are used for anti-cancer chemotheraputics, treated cells self-destruct because cut cannot be rejoined

14

Telomerase

Reverse transcriptase that adds sequence to 3' end of chromosome

15

Nucleolus

Specialized location for the rDNA component (rDNA/rRNA synthesis and ribosome assemly), not membrane bound

16

Chromatin

DNA + protein (nucleosome) complex

17

Euchromatin

Stains lightly, less compact, transcriptionally active

18

Heterochromatin

Stains darkly, transcriptionally inactive