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Flashcards in signal transduction flash Deck (16)
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2

Growth factor

Stimulates cell to leave Go, functions through signal transduction

3

EGF

epidermal GF.

4

PDGF

platelet derived GF

5

FGF

fibroblast GF

6

NGF

nerve GF

7

TGT-alpha

transforming GF

8

TGF-beta

transforming GF. Targets everything

9

raf

MAPKKK. Ser/ Thr kinase. Requires ras to become active

10

ras

GTP binding protein

11

PKB (Akt)

Stimulates cell cycle progression and inhibits apoptosis. GF-->PI3-->PKB

12

Bcl-2

pro and anti-apoptotic

13

BAD

pro-apoptotic factor, phosphorylated and inactivated by PKB

14

E2F

TF that is inhibited by Rb (regulated by cyclin) to keep TF from transcription of genes to enter S phase

15

p53

recognizes damaged DNA and acts as TF to stop cell cyclin by inducing CKI

16

BRCA1

Inhibit cell cycle, repair of damaged DNA