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Flashcards in FA flash Deck (22)
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2

FA synthesis

cytoplasm

3

FA degradation

mitohondria

4

Palmitate

C16:0

5

Sterate

C18:0

6

Oleate

cis9 C18:1

7

Linoleate

cis9, 12 C18:2

8

Linolenate

cis 9,12,15 C18:3

9

Triacylglycerol

Glycerol + 3 FA

10

Hormone sensitive lipase

FA degradative enzyme TG-->glycerol + 3FFA. Activated: elevated cAMP phosphorylates PKA. Inhibited by KB.

11

Glycerol kinase

Glycerol-->Glycerol-3P. Only found in liver.

12

VLCAD

Very long chain ac-CoA DH. Peroxisomal only. Electrons transferred from FADH2 to O2 to produce H2O2, poor energy source due to e- passing

13

FA oxidation yield C18:0

8 FADH2, 8 NADH, 9 Ac-CoA (10 ATP each), -2ATP overall in order to activate FA

14

FA ox. Yield with unsat. At odd carbon

Lose 1.5ATP (lost FADH2)

15

FA ox. Yield with unsat. At even carbon

Lose 2.5 ATP (lost NADH)

16

Propionyl CoA Carboxylase

Odd chain FA oxidation. Propionyl-CoA --> D-methyl-malonyl CoA. Requires biotin (like pyruvate carboxylase)

17

Methyl-malonyl-CoA mutase

L-methyl-malonyl CoA--> succinyl CoA. Requires B12

18

alpha-oxidation

Oxidize alpha carbon of branched chain FA (obtained from diet)

19

w-oxidation

w-carbon oxidized to alcohol

20

KB

acetoacetic acid, beta-hydroxy butyric acid, acetone. Made when Ac-CoA is high in mitochondria. Alternative glucose fuel source

21

Malonyl-CoA

Used as nucleophile in FA biosynthesis. Cannot enter mitochondria, inhibitor of CAT1

22

Acetyl-CoA carboxylase

Enzyme that makes FA. Ac-CoA --> malonyl-CoA. Occurs in ER. Phosphorylated by AMP activated protein kinase and INACTIVATED. Activated by citrate. Stops FA degrdation