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Flashcards in glycogen flash Deck (16)
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2

Glycogen phosphorylase

Degrade glycogen by breaking alpha (1,4) to release G1P. Can work up to 4 residues from alpha (1,6) (dextrin). Requires B6 (pyridoxal phosphate). On same enzyme as debranching enzyme

3

Debranching enzyme

Degrade branch points in glycogen by breaking alpha (1,4) and creating a new alpha (1,4) on main branch. Also breaks alpha (1,6) to make free glucose. On same enzyme asglycogen phosphorylase

4

Glycogen synthase

Make glycogen by adding 1 glucose from UDP-glucose

5

Phosphorylase kinase

Regulate glycogen phosphorylase activity

6

Protein phosphatase 1

Dephosphorylate protein

7

Protein inhibitor 1

Regulate the phosphatase

8

Branching enzyme

Break alpha(1,4) and make alpha(1,6), transfer 5-8 residues

9

glycogenin

Enzyme that addes first 6 glucose to itself to make glycogen primer with glycogen initiator synthetase activity

10

ras

GTP binding protein

11

PKB (Akt)

Stimulates cell cycle progression and inhibits apoptosis. GF-->PI3-->PKB

12

Bcl-2

pro and anti-apoptotic

13

BAD

pro-apoptotic factor, phosphorylated and inactivated by PKB

14

E2F

TF that is inhibited by Rb (regulated by cyclin) to keep TF from transcription of genes to enter S phase

15

p53

recognizes damaged DNA and acts as TF to stop cell cyclin by inducing CKI

16

BRCA1

Inhibit cell cycle, repair of damaged DNA