Drug Quiz 5 Flashcards Preview

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Flashcards in Drug Quiz 5 Deck (73):
1

aspirin drug class

platelet aggregation inhibitor/anti-inflammatory

2

aspirin MOA

blocks formaton of thromboxane A2 prevents platelet aggregation; cox inhibitor, inhibits prostaglandin synthesis

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aspirin onset of action

5-30 min

4

aspirin peak effects

15-120 min

5

aspirin duration of effect

1-4 hrs

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aspirin half life

15-20 min

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aspirin indications

chest pain suggestion of ami/acs

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aspirin contraindications

hypersensitivity, active ulcer, asthma

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aspirin side effects

gi bleeding, wheezing, n+v, heartburn

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aspirin adult dose

160-325mg

11

aspirin pedi dose

not for pedi

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aspirin precautions

can cause gi upset/bleeding

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aspirin interactions

with other anti-inflammatories cause increased side effects; with antacid decreased absorption

14

morphine drug class

narcotic analgesic

15

morphine MOA

opiate R agonist, causes CNS depression, decreases preload and myocardial oxygen demand

16

morphine onset of action

immediate iv, 15-30 min im

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morphine peak effects

20 min iv; 30-60 im

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morphine duration of effect

2-7 hrs

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morphine half life

1-7 hrs

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morphine indications

severe pain, pulmonary edema

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morphine contraindications

hypovolemia/hypotension; AMS; hypersensitivity; COPD/ compromised respiratory status

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morphine side effects

nausea/vomitting, constricted pupils, AMS, respiratory depression

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morphine adult dose

2-10mg iv initial, then 2mg q3-5

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morphine pedi dose

0.1mg/kg iv

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morphine precautions

respiratory depression, have narcan available

26

morhine interactions

additive effects with antihistamines, antiemetics, sedatives, hypnotics, barbituates, alcohol

27

ondansetron trade name

zofran

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zofran generic name

ondansetron

29

zofran drug class

anti-emetic

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zofran MOA

serotinin R antagonist, especially at vagal nerve terminals

31

zofran onset of action

10-30 min

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zofran peak effects

unknown

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zofran duration of effects

unknown

34

zofran half life

4 hrs

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zofran indications

nausea/vomitting

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zofran contraindications

hypersensitivity

37

zofran side effects

prolonged QT interval, HA, dizziness, tachycardia

38

zofran adult dose

4mg iv over 2-5 min

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zofran pedi dose

0.1 mg/kg iv over 2-5 min

40

zofran precautions

lower risk of sedation and dystonia than other antiemetics

41

zofran drug interactions

may effect clearance and half life with inducers and inhibitors of cytochrome p-450 enzymes

42

nitro trade name

nitrostat

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nitro MOA

pro drug converted to nitric oxide, activates conversion of GTP to cGMP + 2Pi in VSMC, reduces intracellular Ca2+ causing VSMC relaxation, decreasing preload and afterload

44

nitro onset of action

1-3 min SL, 30 min topical

45

nitro peak effects

5-10 min SL, varies topical

46

nitro duration of effect

20-30 min SL, 3-6 hrs topical

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nitro half life

1-4 min

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nitro indications

chest pain of cardiac origin, acute pulmonary edema/CHF

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nitro contraindications

systolic<100; ICP, children under 12, ED drugs w/in 48 hrs

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nitro side effects

HA, dizziness, hypotension, tachycardia

51

nitro spray dose

0.4mg SL q3-5 (max 3x25min)

52

nitro paste dose

0.5-1 inch

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nitro tablet dose

0.4mg SL

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nitro pedi dose

not for kids

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nitro precautions

monitor vitals, 12 lead prior to administration, caution w/ R sided MI

56

nitro interactions

orthostatic hypotension w/ b-blockers, severe hypotension w/ alcohol

57

epinephrine trade name

adrenalin, epipen

58

epi drug class

sympathomimetic, catecholamine

59

epi moa

a1 agonist causing peripheral vasoconstriction; b1 agonist causing positive inotropy, chronotropy, dromotropy; b2 agonist causing bronchodilation; blocks destruction of MAST cells

60

epi onset of action

<2 min IV, 3-10 min IM

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epi peak effects

<5 min IV, 20 min IM

62

epi duration of effect

5-10 min IV, 20-30 min IM

63

epi half-life

5 min

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epi indications

cardiac arrest, anaphylaxis, symptomatic bradycardia

65

epi contraindications

HTN and tachydysrhythmias, caution with pregnancy and CAD

66

epi side effects

anxiety, HA, dysrhythmias, tremulousness

67

epi adult cardiac arrest dose

0.5-1mg iv [1:10,000] q3-5

68

epi pedi cardiac arrest dose

0.01mg/kg iv [1:10,000] q3-5

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epi bradycardia/hypotension dose

2-10 mcg/min

70

epi anaphylaxis adult dose

0.3-0.5mg im [1:1,000], then 0.1mg [1:10,000] iv over 3 min

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epi pedi anaphylaxis dose

0.01mg/kg im [1:1,000], then 0.01mg/kg [1:10,000 iv (max of 0.3mg)

72

epi precautions

protect from light

73

epi drug interactions

inactivated by alkalinity, effects intensified with antidepressants, forms ppt with CaCl2 and NaHCO3