drugs

Question 1

moa of methotrexate

Answer 1

inhibits dihydrofolate reductase

Question 2

adverse effects of methotrexate

Answer 2

mucositis
myelosuppression
pneumonitis (most common- develops within a year of starting)
pulmonary fibrosis
liver fibrosis

Question 3

pregnancy guidelines for methotrexate

Answer 3

man and women should stop methotrexate 6 months before getting pregnant

Question 4

interactions with methotrexate

Answer 4

avoid prescribing trimethoprim or co-trimoxazole
aspirin increases the of methotrexate toxicity

Question 5

treatment of methotrexate toxicity

Answer 5

folinic acid

Question 6

cautions with sulfasalazine

Answer 6

G6PD deficiency
allergy to aspirin or sulphonamides

Question 7

adverse effects of sulfasalazine

Answer 7

oligospermia
stevens-johnson syndrome
penumonitis/lung fibrosis
myelosuppression, heinz body anaemia, megaloblastic anaemia
may colour tears

Question 8

what to look for for asathioprine toxicity

Answer 8

thiopurine methyltransferase test

Question 9

adverse effects of azathioprine

Answer 9

bone marrow depression
nausea/vomiting
pancreatitis
increased risk of non-melanoma skin cancer

Question 10

interactions with azathioprine

Answer 10

allopurinol