systemic lupus erythematosus

Question 1

general features of SLE

Answer 1

fatigue
fever
mouth ulcers
lymphadenopathy

Question 2

skin changes in SLE

Answer 2

malar rash
discoid rash: well demarcated in sun-exposed areas
photosensitivity
raynauds
livedo reticularis
non scarring alopecia

Question 3

msk features of SLE

Answer 3

arthralgia
non-erosive arthritis

Question 4

cardiovascular features of SLE

Answer 4

pericarditis
myocarditis

Question 5

respiratory features of SLE

Answer 5

pleurisy
fibrosing alveolitis

Question 6

renal features of SLE

Answer 6

proteinuria
glomerulonephritis

Question 7

neuropsych features of SLE

Answer 7

anxiety and depression
psychosis
seizure

Question 8

antibodies for SLE

Answer 8

99% ANA positive: low specificity
anti-dsDNA (highly specific low sensitivity)
RF positive (20%)
anti-smith

Question 9

monitoring for SLE

Answer 9

inflammatory markers: ESR
complement levels are low during active disease
anti-dsDNA can be used to monitor

Question 10

management of SLE

Answer 10

basic: NSAIDs and sun-block
hydroxychloroquine
if internal organ involvement consider prednisolone or cyclophosphamide