Drugs on Smooth Muscles

Question 1

Amino acid precursor of histamine

Answer 1

histidine

Question 2

[Histamine receptor]

Smooth muscle

Answer 2

H1, Gq, increase IP3/DAG

Question 3

[Histamine receptor]

stomach

Answer 3

H2, Gs, increase cAMP

Question 4

[Histamine receptor]

brain

Answer 4

H3, decrease cAMP

Question 5

[Histamine receptor]

for leukocyte chemotaxis

Answer 5

H4, decrease cAMP

Question 6

Antiemetic first generation antihistamine

Answer 6

promethazine

Question 7

First generation antihistamine used in treating serotonin syndrome

Answer 7

Cyproheptadine

Question 8

The dreaded side effect of first generation antihistamine

Answer 8

orsthostatic hypotension

Question 9

A first generation antihistamine that has more antimotion sickness action than sedative action

Answer 9

Cyclizine

Question 10

A first generation antihistamine with less antimotion sickness action, more sedative and autonomic effects

Answer 10

promethazine

Question 11

generation of antihistamine that has no autonomic or antimotion sickness effect

Answer 11

Second generation H1 antagonist

Question 12

Fatal arrhythmias can happen if the second generation antagonists, Terfenadine/Astemizole, are combined with this macrolide

Answer 12

Erythromycin

Question 13

Fatal arrhythmias can happen if the second generation antagonists, Terfenadine/Astemizole, are combined with this antifungals

Answer 13

Azoles

Question 14

Cite examples of H2 receptor antagonists

Answer 14

1. Cimetidine
2. Ranitidine
3. Famotidine
4. Nizatidine

Question 15

H2 receptor antagonist that has antiandrogen effect

Answer 15

cimetidine

Question 16

H2 receptor antagonist that has decreased hepatic flow

Answer 16

cimetidine

Question 17

H2 receptor antagonis that is used in the ICU setting to prevent gastric erosion

Answer 17

ranitidine

Question 18

H2 receptor antagonist that is used to reduce nocturnal acid secretion and duodenal ulcer

Answer 18

Ranitidine

Question 19

Serotonin is derived from what amino acid?

Answer 19

tryptophan

Question 20

[Serotonin receptors]

Brain

Answer 20

5-HT 1D, Gi, decrease cAMP

Question 21

[Serotonin receptors]

smooth muscle

Answer 21

5HT2, Gq, increase IP3/DAG

Question 22

[Serotonin receptors]

platelets

Answer 22

5HT2, Gq, increase IP3/DAG

Question 23

[Serotonin receptors]

area postrema

Answer 23

5HT3, ligand gated

Question 24

[Serotonin receptors]

presynaptic terminal in the enteric nervous system

Answer 24

5-HT4, Gs, increase cAMP

Question 25

What is the DOC for acute migraine/cluster headache

Answer 25

-Triptans 5HT1D receptor agonists

Question 26

Drug used for postchemo/post operative vomiting

Answer 26

Ondansetron 5HT3 receptor antagonist

Question 27

5HT3 receptor antagonist used for Irritable bowel disease

Answer 27

Alosetron

Question 28

5HT3 receptor antagonist that has a SE of QRS and QT prolongation

Answer 28

Dolasetron

Question 29

5HT3 receptor antagonist that has a SE of constipation

Answer 29

Alosetron

Question 30

Responsible for the epidemics of St. Anthony's fire

Answer 30

Ergot alkaloids

Question 31

Cite examples of vasoselective 5HT2 receptor antagonist

Answer 31

1. Ergotamine 2. Dihydroergotamine 3. Methysergide

Question 32

Ergotamine is a partial agonist on what receptors?

Answer 32

1. alpha | 2. 5HT 2 receptors

Question 33

Ergotamine has a potent agonist effect on what receptors?

Answer 33

dopamine receptors

Question 34

5HT2 receptor antagonist that has a SE of retroperitoneal fibrosis?

Answer 34

methysergide

Question 35

histamine antagonist class that cause epinephrine reversal due to its partial agonist effect on alpha receptors

Answer 35

5HT2 receptor antagonist

Question 36

What is the antidote for ergotamine toxicity?

Answer 36

Nitroprusside

Question 37

Cite examples of uteroselective antihisaminse

Answer 37

1. Ergonovine | 2. Methylergonovine

Question 38

Drug of choice for post partum bleeding

Answer 38

Methylergonovine

Question 39

___ is a strong h3 receptor antagonist; used for balance disorders or to alleviate vertigo symptoms

Answer 39

Betahistine

Question 40

A drug that is both an antihistamine and CCB; used to treat cerebral apoplexy and post trauma cerebral symptoms and cerebral arteriosclerosis

Answer 40

cinnarazine

Question 41

A calcium entry blocker with calmudolin binding properties and H1 antagonistic activity; prophylaxis of migraine, occlusive peripheral vascular disease, vertigo and adjuvant for epilepsy

Answer 41

flunarazine

Question 42

Drug of choice for diabetic gastroparesis

Answer 42

Metoclopramide