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Pharmacology > Opioid Antagonist > Flashcards

Opioid Antagonist Flashcards

(52 cards)

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1
Q

Opioid receptor responsible for inhibition of respiration

A

Mu

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2
Q

Opioid receptor responsible for development of tolerance

A

Delta

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3
Q

Opioid receptor responsible for slowing the GI transit

A

Kappa

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4
Q

[Opioid agonist: full]

SE: miosis

A

morphine

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5
Q

[Opioid agonist: full]

has a hemodynamic effect on the pulmonary ciculation

A

morphine

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6
Q

[Opioid agonist: full]

can be used as pain reliever in acute PI

A

morphine

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7
Q

[Opioid agonist: full]

given transdermal, for breakthrough cancer pain

A

fentanyl

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8
Q

[Opioid agonist: full]

causes hypertensive crisis when taken with tyramin

A

meperidine

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9
Q

[Opioid agonist: full]

used for spasmodic pain

A

meperidine

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10
Q

[Opioid agonist: full]

used to treat opioid dependence/withdrawal

A

methadone

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11
Q

What are examples of your partial opioid agonist

A

hydrocodone, dextromethorphan

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12
Q

[Opioid agonist: partial]

can caue hypogonadism, hearing loss

A

hydroxycodone

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13
Q

[Opioid agonist: partial]

decreases sensitivity of cough receptors

A

dextromethorphan

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14
Q

What are the side effects of morphine

A
  1. Miosis
  2. Restlessness
  3. Respiratory depression
  4. Postural hypotension
  5. Increase ICP
  6. Constipation
  7. urinary retention
  8. pruritus
  9. addiction liability
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15
Q

[Opioid agonist: weak]

examples of weak opioid agonist

A
  1. Propoxyphene
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16
Q

[Opioid agonist: weak

that can be used to treat restless leg syndrome

A

propoxyphene

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17
Q

[Opioid: mixed]

cite examples

A
  1. Nalbuphine
  2. Butorphanol
  3. Buprenorphine
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18
Q

[Opioid: mixed]

Can be used to reduce craving in alcohol dependence

A
  1. Nalbuphine
  2. Buprenorphine

resistant to naloxone reversal

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19
Q

[Opioid: antagonist]

MOA of naloxone

A

competitive inhibitor at mu, delta, kappa

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20
Q

[Opioid: antagonist]

used to treat opioid and alcohol dependence

A

naltrexone

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21
Q

[Opioid: dual acting]

MOA of tramadol

Study These Flashcards
A

weak agonist at mu

22
Q

[Opioid: dual acting]

tramadol cannot be used in patient with history of

23
Q

[Opioid: dual acting]

can cause serotonin syndrome when used with SSRI

24
Q

[General anesthesia: inhaled]

for dental procedures

Study These Flashcards
A

Nitrous oxide

25
[General anesthesia: inhaled] causes megaloblastic anemia and bronchodilation
nitrous oxide
26
[General anesthesia: inhaled] lowest potency highest MAC
nitrous oxide
27
[General anesthesia: inhaled] can cause bronchospasm
desflurane
28
[General anesthesia: inhaled] can cause renal insufficiency
sevoflurane, methoxyflurane
29
[General anesthesia: inhaled] can cause catecholamine induced arrythmias
Isoflurane
30
[General anesthesia: inhaled] has a spike and wave activity in EEG
Enflurane
31
[General anesthesia: inhaled] In used with succinylcholine can cause malignant hyperthermia
halothane
32
[General anesthesia: IV] increases duration of Cl channel
barbiturates
33
[General anesthesia: IV] can cause acute intermittent porphyria
barbiturates
34
[General anesthesia: IV] has rapid entry to the brain
barbiturates
35
[General anesthesia: IV] cause anterograde amnesia
Benzodiazepines
36
Antidote of Midazolam
Flumazenil
37
[General anesthesia: IV] can cause dissociative amnesia
ketamine
38
[General anesthesia: IV] emergence delirium as post-op effect
ketamine
39
to reduce emergence delirium due to ketamine, what will you give
benzodiazepine
40
What happens when you give droperidol and NO?
Neuroleptanesthesia
41
[General anesthesia: Miscellaneous] can be used for patients with limited cardiorespiratory reserve
etomidate
42
[General anesthesia: Miscellaneous] cause post-op N/V
etomidate
43
Milk of amnesia
propofol
44
[General anesthesia: Miscellaneous] Alpha 2 receptor agonist decrease sympathetic tone attenuates neuroendocrine with hemodynamic response to anesthesia and surgery
dexmetomidine
45
Most allergenic among all local anesthetics?
tetracaine
46
only local anesthesia that vasoconstricts
cocaine
47
Antiarrhythmic local anesthesia used post-MI
Lidocaine
48
To decrease systemic absorption of lidocaine, this can be given
epinephrine
49
Local anesthesia used in dental procedures
prilocaine
50
Local anesthesia which can cause methemoglobinemia
prilocaine
51
what drug will you give to counter methemoglobinemia
methylene blue
52
Bupivacaine cardiotoxicity can be treated with
Intralipid/Liposomal forms

Pharmacology (35 decks)

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