Hypothalamic and Pituitary Drugs

Question 1

Among the pituitary hormones, which are potent vasoconstrictors

Answer 1

1. Vassopressin
2. Oxytocin

All posterior pituitary

Question 2

[Growth Hormone]

Drug with agonist action

Answer 2

1. Somatropin

2. Mecasermin

Question 3

[Growth Hormone]

Drug with antagonist action

Answer 3

1. Octreotide

2. Pegvisomant

Question 4

[Gonadotropin]

Drug with LH agonist action

Answer 4

1. Lutropin

2. hCG

Question 5

[Gonadotropin]

Drug with FSH agonist action

Answer 5

Follitropin

Question 6

[Gonadotropin]

Drug with mixed LH and FSH agonist action

Answer 6

Menotropin

Question 7

Drug that has a prolactin antagonist action

Answer 7

Bromocriptine (D2 dopamine agonist)

Question 8

Drug with GnRH Agonist action

Answer 8

Gonadorelin

Question 9

Drug with GnRH receptor agonist action

Answer 9

Leuprolide

Question 10

Drug with GnRH receptor antagonist action

Answer 10

Ganirelix

Question 11

Drug with ADH agonist action

Answer 11

Desmopressin

Question 12

Drug with ADH antagonist action

Answer 12

Conivaptan

Question 13

Drug with oxytocin agonist action

Answer 13

Oxytocin

Question 14

Drug with Oxytocin antagonist action

Answer 14

Atosiban

Question 15

Drug that increases the release of IGF-1 in the liver and cartilage

Answer 15

Somatropin

Question 16

DOC for patients with Turner, Noonan, Prader-Willi (with short stature)

Answer 16

Somatropin - recombinant growth hormine

Question 17

DOC to improve GI function in patients who underwent intestinal resection that lead to malabsorption syndrome

Answer 17

Somatropin

Question 18

Recombinant IGF-1 agonist; or patients unresponsive to GH therapy

Answer 18

Mecasermin

Question 19

What drug can be given to patients with acromegaly?

Answer 19

Pegvisomant

Question 20

DOC for GH-secreting pituitary adenoma

Answer 20

Octreotide

Also be given for gastrinoma, glucagonoma, carcinoid

Question 21

[Ovulation Induction Protocol]

Follicle development is driven by daily injections of these drugs

Answer 21

1. Menotropins
2. FSH
3. FSH analog

Question 22

[Ovulation Induction Protocol]

What is injected to induce on the final stage of oocyte maturation

Answer 22

1. LH or

2. hCG

Question 23

What is the DOC for infertility due to hypogonadotropic hypogonadism in men?

Answer 23

1. Follitropin

Question 24

A FSH analog that is a purified preparation from the urine of postmenopausal women

Answer 24

urofollitropin

Question 25

DOC for initiation of ovulation during controlled ovarian hyperstimulation

Answer 25

Choriogonadotropin

Question 26

DOC for ovarian follicle development with hypogonadotropic hypogonadism in women

Answer 26

Choriogonadotropin alpha

Question 27

Intermittent administration of leuprolide can lead to ____ (increase/decrease) of LH and FSH

Answer 27

Increase

Question 28

Continous administration of Leuprolide can lead to ____ (increase/decrease) of LH and FSH

Answer 28

Decrease due to down regulation of GnRH receptors in the pituitary cells

Question 29

What is the DOC for patients with precocious puberty

Answer 29

Leuprolide

Question 30

Advanced prostate CA can be injected with this drug class; it can lead to temporary exacerbation or tumor flare up

Answer 30

1. GnRH analog (Leuprolide)

Question 31

What will you give for patients experiencing apoplexy and blindness during the first week of therapy withleuprolide?

Answer 31

Give FLUTAMIDE (androgen receptor antagonist)

Question 32

What is the DOC to prevent premature LH surge during controlled ovarian hyperstimulation

Answer 32

GnRH antagonist Ganirelix

Question 33

Advanced prostate CA can be injected with this drug class; doe not cause tumor flare up

Answer 33

GnRH antagonist Degarelix

Question 34

Dopamine agonist that inhibits prolactin release from the pituitary gland; slightly inhibits GH release

Answer 34

1. Bromocroptine | 2. Pergolide

Question 35

Method of administration of Bromocriptine in women with hyperprolactinemia

Answer 35

Vaginally

Question 36

Bromocriptine is contraindicated in patients with ____

Answer 36

psychotic illness

Question 37

____ is a rare disorder characterized by burning and warmth of the extremities; SE of bromocriptine

Answer 37

Erythromelalgia

Question 38

What are the contraindications to giving oxytocin

Answer 38

1. Fetal distress 2. Prematurity 3. Abnormal presentation 4. CPD 5. Predisposition for uterine rupture

Question 39

Drug that is an oxytocin receptor blocker

Answer 39

Atosiban

Question 40

Drug that is an agonist of peripheral oxytocin receptors

Answer 40

Carbetocin

Question 41

Desmopressin is selective for what ADH receptor

Answer 41

V2

Question 42

What ADH agonist is used to treat esophageal varices or colon diverticula

Answer 42

Desmopressin Contracts vascular smooth muscle via V1 receptor leading to vasoconstriction

Question 43

[Diagnose] polyuria, polydipsia, hypernatremia

Answer 43

Diabetes Insipidus

Question 44

ADH antagonist used to treat SIADH, Hyponatremia in hospitalized patients

Answer 44

Conivaptan

Question 45

What drug selectively inhibits V2 receptor

Answer 45

1. Lixivaptan | 2. Tolvaptan