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Pharmacology > Renal Drugs > Flashcards

Renal Drugs Flashcards

(55 cards)

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1
Q

[Diuretics]

site of action of carbonic anhydrase inhibitors

A

PCT

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2
Q

[Diuretics]

DOC for mountain sickness

A

Acetazolamide

MOA: interfere with HCO3 reabsorption; inhibits carbonic anhydrase

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3
Q

[Diuretics]

used to in glaucoma since it has the ability to decrease secretion of aqueous humor

A

acetazolamide

MOA: interfere with HCO3 reabsorption; inhibits carbonic anhydrase

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4
Q

[Loop Diuretics]

site of action of Furosemide

A

THICK ascending loop of Henle

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5
Q

[Loop Diuretics]

The transporter affected by furosemide

A

NaK2Cl transporter

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6
Q

Which part of the kidney is the site of calcium and magnesium reabsorption

A

Thick Ascending loop of henle

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7
Q

What drug class decreases the efficacy of your loop diuretics

A

NSAIDs

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8
Q

[Loop Diuretics]

causes ototoxicity

A

Furosemide

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9
Q

[Loop Diuretics]

What are the electrolyte imbalances associated with intake of furosemide?

A
  1. Hyperuricemia
  2. Hypokalemia
  3. Hypomagnesemia
  4. Hypocalcemia
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10
Q

[Loop Diuretics]

What are the adverse effects of your loop diuretics?

A

OH DANG

  1. Ototoxicity
  2. Hypokalemia
  3. Dehydration
  4. Allergy to Sulfa
  5. Nephritis
  6. gout
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11
Q

Thiazide diuretics acts on this transporter

A

NaCl carrier

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12
Q

Site of action of thiazide diuretics

A

Distal Convoluted tubule

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13
Q

Segment of the nephron affected by PTH

A

DCT

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14
Q

What are the adverse effects of your thiazide diuretics

A

HyperGLUC

  1. hyperGlycemia
  2. hyperLipidemia
  3. hyperUricemia
  4. hyperCalcemia
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15
Q

Diuretic of choice for nephrogenic diabetes insipidus

A

Thiazide diuretics

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16
Q

Diuretic that is contraindicated in patients with DM

A

Thiazide diuretics

Can cause hyperpolarization of ATP dependent K channels which means no insulin release thus hyperglycemia

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17
Q

Site of action of aldosterone resulting to Na reabsorption

A

Cortical Collecting Duct

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18
Q

Which part of the nephron is termed as the primary side of urine acidification

A

Cortical collecting duct

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19
Q

Site of action of potassium-sparing diuretics

A

Cortical collecting duct

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20
Q

Diuretic of choice in hyperaldosteronism

A

Spironolactone

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21
Q

What is the MOA of Eplerenone

A

Its a K-sparing diuretic

MOA: Steroid inhbitors of cytoplasmic aldosterone receptor in CCD, reduces K excretion

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22
Q

Potassium sparing diiuretic that reduces progression of DM nephropathy and reduces mortality post MI

A

Eplerenone

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23
Q

Diuretic that can cause gynecomastia

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A

Spironolactone

24
Q

Potassium sparing diuretic that is beneficial in patients with CHD since it helps in the management of cardiac remodeling

Study These Flashcards
A

Spironolactone

25
Drug that inhibits ENaC epithelial sodium channels in the CCD, reducing Na reabsorption and K excretion
1. Amiloride | 2. Triamterene
26
These diuretics should not be given with patients taking potassium supplements
1. Amiloride | 2. Triamterene
27
The indication of these diuretics are for patients with hypokalemia
1. Amiloride | 2. Triamterene
28
What are the examples of you potassium sparing diuretics
1. Spironolactone 2. Triamterene 3. Amiloride 4. Eplerenone STAE(y)
29
What are the drugs that can cause gynecomastia?
C-KADS 1. Cimetidine 2. Ketoconazole 3. Alcohol 4. Digoxin 5. Spironolactone
30
Diuretic used in patients with increased intracranial pressure
Mannitol
31
Diuretic used in patients with acute glaucoma
Mannitol
32
Diuretic used to maintain high urine flow
Mannitol
33
What hormone plays a role in the reabsorption of water
ADH
34
Vasocpressin is an ADH agonist at what ADH receptors?
Both V1 and V2
35
Diuretic of choice for nocturnal enuresis
Vasopressin
36
Diuretic used to treat vWF disease
Vassopressin
37
Diuretic that is not recommended during pregnancy since it can cause uterine contraction and increased uterine pressure in early pregnancy
Terlipressin
38
Which factor increases after administration of vasopressin?
1. Factor 8 | 2. vWF disease
39
Diuretic of choice for central diabetes insipidus
Vasopressin
40
Diuretic of choice for SIADH
Conivaptan
41
What mineral which acts as ADH antagonist and used in SIADH?
Lithium
42
What is the adverse effect of rapid correction of hyponatremia?
Central pontine myelinosis
43
Urine Calcium concentration increases in which diuretic class?
Loop diuretics
44
Diuretic drug class that can cause alkalemia
1. Loop diuretics | 2. Thiazide diuretics
45
Diuretic drug class that can cause acidemia
1. Carbonic anydrase inhibitors | 2. K sparing diuretics
46
Drug that can be used to treat pulmonary artery hypertension since it has a dual endothelin receptor antagonist activity
Bosentan
47
Alpha 1 antagonist that does not elicit reflex tachycardia; acts at the 5HT1A agonist also
Urapidil
48
Cerebral activators used in traumatic brain injury (like SAH) since it stabilizes cell membrane and reduces free radicals
Citicoline
49
Beta 2 adrenoceptor agonist that causes direct relaxation of uterine and vascular smooth muscle; used to treat premature labor and vasodilator for reynaud's phenomenon
Isoxuprine
50
An antihistamine drug used to treat cerebral apoplexy, post trauma cerebral symptoms;
Cinnarazine
51
SGLT2 inhibitor
Canagliflozin, Dapagliflozin
52
What is a drug that is not a sulfonamide but has a typical loop activity and some uricosuric action
Ethacrynic acid
53
What is the only parenteral thiazide available?
Chlorothiazide
54
What is the DOC for Liddle's Syndrome
Amiloride
55
DOC for lithium induced polyuria
Amiloride

Pharmacology (35 decks)

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